Division of Translational Medicine & Human Genetics, University of Pennsylvania, Philadelphia, PA, USA.
Division of Translational Medicine & Human Genetics, University of Pennsylvania, Philadelphia, PA, USA.
J Clin Lipidol. 2024 Sep-Oct;18(5):e873-e876. doi: 10.1016/j.jacl.2024.07.012. Epub 2024 Aug 3.
Guidelines recommend checking lipoprotein(a) [Lp(a)] levels in patients at high-risk for cardiovascular disease, with more recent recommendations advocating for universal screening in all adults. A brief electronic survey was distributed to select groups of University of Pennsylvania Health System (UPHS) providers, including Internal Medicine and Cardiology physicians and advance practice providers, to understand the current attitudes and barriers to testing for Lp(a). Of the 126 survey respondents, only 31% answered that they test for Lp(a) regularly in their practice. Presence of ASCVD and a family history of ASCVD were the most common reasons for testing. Most survey respondents (69%) replied that they do not currently check Lp(a) levels in patients. The most common reasons provided included lack of familiarity with Lp(a), insurance/ billing concerns, lack of clinical trial outcomes data, and lack of available pharmaceutical interventions. Results from ongoing clinical trials of novel Lp(a)-lowering therapies, if successful, may address provider hesitation toward Lp(a)-testing, but there remains a large gap to fill in awareness of Lp(a).
指南建议对心血管疾病高危患者检查脂蛋白(a)[Lp(a)]水平,最近的建议则主张对所有成年人进行普遍筛查。我们向宾夕法尼亚大学健康系统(UPHS)的一些选定群体的医务人员,包括内科医生和心脏病专家以及高级执业护士,分发了一份简短的电子调查问卷,以了解目前检测 Lp(a)的态度和障碍。在 126 名调查对象中,只有 31%的人回答他们在常规实践中检测 Lp(a)。存在 ASCVD 和 ASCVD 家族史是检测的最常见原因。大多数调查对象(69%)表示他们目前不会在患者中检查 Lp(a)水平。最常见的原因包括不熟悉 Lp(a)、保险/计费问题、缺乏临床试验结果数据以及缺乏可用的药物干预措施。正在进行的新型 Lp(a)降低疗法的临床试验结果如果成功,可能会解决提供者对 Lp(a)检测的犹豫,但在认识 Lp(a)方面仍有很大的差距需要填补。