Service de neurologie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris, France.
Service de neurologie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris, France; Paris-Diderot, université de Paris, 75010 Paris, France.
Rev Neurol (Paris). 2024 Nov;180(9):989-994. doi: 10.1016/j.neurol.2024.07.005. Epub 2024 Sep 16.
Chimeric antigen receptor T-cell (CAR T-cell) therapies have emerged as a promising treatment modality for several malignancies, particularly haematological malignancies, by inducing robust antitumour responses. However, CAR T-cell therapies are associated with a spectrum of adverse events, including neurological complications. We here provide a review of neurological adverse events observed in patients undergoing CAR T-cell therapy, focusing on their incidence, clinical manifestations, underlying mechanisms and potential management strategies.
嵌合抗原受体 T 细胞（CAR T 细胞）疗法通过诱导强大的抗肿瘤反应，已成为多种恶性肿瘤（尤其是血液系统恶性肿瘤）的一种有前途的治疗方法。然而，CAR T 细胞疗法与一系列不良事件相关，包括神经并发症。本文就接受 CAR T 细胞治疗的患者中观察到的神经不良事件进行综述，重点介绍其发生率、临床表现、潜在机制和潜在管理策略。
