Bhattacharya Amrapali, Chakraborty Kanak, Saha Partha, Saha Susmita, Roychaudhuri Parichita, Baidya Jahar Lal, Ghosh Arabinda, Chakraborty Debaprasad, Sengupta Sharmila, Sil Samir Kumar
National Institute of Biomedical Genomics, Kalyani, West Bengal, India.
Cell Physiology and Molecular Genetics Laboratory, Department of Human Physiology, Tripura University Suryamaninagar, Tripura, India.
Am J Epidemiol. 2024 Sep 17. doi: 10.1093/aje/kwae364.
The current study explored HPV prevalence and age variation in cervical samples of different cytological categories and HPV types from women seeking gynecological care in Tripura, northeast India. Pap smears, cervical tissues, and HPV/DNA specimens were collected from gynecological outpatient departments (OPD) or in-house patients and were screened for HPV16, HPV18, and other HPV types by PCR. Finally, logistic regression was performed to find the association between epidemiologic factors and HPV infection in women of different cytological grades. About 90% of HPV-screened women were found to be HPV positive. HPV16 was most common in HPV-positive women (53.27%), followed by HPV16/18 co-infection (26.17%). HPV16 or HPV18 was most frequent (86.45%) compared to others (13.55%). Among the confirmed cytological tests 68.83% showed normal cytology and 37.17% showed atypical abrasions. Among the abnormal cytology participants, 94.37% were HPV-positive, and 42.25% had cervical cancer. The prevalence of HPV increased with cytological abnormalities (p < 0.01). Abnormal cytological lesions increased with age (p trend = 0.017). Among all epidemiologic factors studied, parity was strongly associated with overall HPV infection, regardless of cytological status. Observed very high frequency of HPV infection in the current study, warrants further investigations.
本研究探讨了印度东北部特里普拉邦寻求妇科护理的女性不同细胞学类别和HPV类型的宫颈样本中HPV的流行情况及年龄差异。从妇科门诊或住院患者中收集巴氏涂片、宫颈组织和HPV/DNA样本，并通过PCR检测HPV16、HPV18和其他HPV类型。最后，进行逻辑回归分析以找出不同细胞学分级女性的流行病学因素与HPV感染之间的关联。约90%接受HPV筛查的女性被发现HPV呈阳性。HPV16在HPV阳性女性中最为常见（53.27%），其次是HPV16/18合并感染（26.17%）。与其他类型相比，HPV16或HPV18最为常见（86.45%），其他类型占13.55%。在确诊的细胞学检查中，68.83%显示细胞学正常，37.17%显示非典型擦伤。在细胞学异常的参与者中，94.37%为HPV阳性，42.25%患有宫颈癌。HPV的流行率随细胞学异常而增加（p<0.01）。异常细胞学病变随年龄增加而增加（p趋势=0.017）。在所有研究的流行病学因素中，无论细胞学状态如何，产次与总体HPV感染密切相关。本研究中观察到的HPV感染频率非常高，值得进一步调查。
