a Department of Gynecology, First Affiliated Hospital of Xinjiang Medical University , Urumqi , Xinjiang , China.
b College of Public Health, Xinjiang Medical University , Urumqi , China.
Hum Vaccin Immunother. 2019;15(7-8):1889-1896. doi: 10.1080/21645515.2019.1578598. Epub 2019 Apr 2.
: Genotype distribution and prevalence of human papillomavirus (HPV) among women vary from different regions and crowds, prophylactic HPV vaccin could prevent some diseases related to HPV, which include cervical precancerous lesions and cancer. Baseline surveys prior to mass HPV vaccination are critical to determine vaccine efficacy and detect changes in HPV type after vaccination. : The aim of this study is to study the HPV type-specific prevalence in 698 women with cytological abnormalities, aging from 18 to 77 years old. Additionally, the association between HPV infection and cervical disease was investigated as well. : A total of 698 cervical specimens of cytological abnormalities were collected from the First Affiliated Hospital of Xinjiang Medical University. The Thinprep liquid-based cytologic test (TCT) was performed and the cytological status was classified according to Bethesda 2001. The samples were tested HPV genotype by the PCR-based hybridization gene chip assay. : Overall, the HPV prevalence was 54.87%, and it was shown to be age dependent, and with the decreasing and zigzag prevalence until the age of 55 years. 204 patients (53.26%) were infected with pure high-risk HPV, 139 (36.30%) with pure low-risk HPV, and 40 (10.44%) with mixed HPV types. HPV16 was the most common type (35.36%), followed by HPV58 (13.62%) and HPV52 (9.15%). In this study, 386 (55.30%) were affected by ASCUS, 11 (1.58%) by ASC-H, 137 (19.63%) by L-SIL and 151 (21.63%) by H-SIL. Women with a cytology result of ASCUS, ASC-H, L-SIL and H-SIL had the infection of HPV 39.12%, 54.17%, 70.80% and 80.79% respectively. : In conclusion, this study presents the first investigation about the prevalence of HPV infection and HPV genotype distribution in Xinjiang women who have abnormal cytological tests. Prior to HPV immunization in Xinjiang's population, our results could be baseline data and validation set, which provide robust available estimates of the prevalence of type-specific HPV.
: 基因型分布和人乳头瘤病毒（HPV）在不同地区和人群中的流行情况有所不同，预防性 HPV 疫苗可以预防与 HPV 相关的一些疾病，包括宫颈癌前病变和癌症。在大规模 HPV 疫苗接种之前进行基线调查对于确定疫苗的效果和检测接种后 HPV 类型的变化至关重要。: 本研究旨在研究 698 例年龄在 18 岁至 77 岁之间细胞学异常的妇女中 HPV 型特异性流行率。此外，还研究了 HPV 感染与宫颈疾病的关系。: 共收集新疆医科大学第一附属医院 698 例细胞学异常宫颈标本。采用 Thinprep 液基细胞学检测（TCT），根据 2001 年贝塞斯达标准对细胞学结果进行分类。采用基于 PCR 的杂交基因芯片法检测 HPV 基因型。: 总体而言，HPV 感染率为 54.87%，呈年龄依赖性，55 岁前呈下降和锯齿状流行。204 例（53.26%）患者感染单纯高危型 HPV，139 例（36.30%）感染单纯低危型 HPV，40 例（10.44%）感染混合 HPV 型。HPV16 是最常见的类型（35.36%），其次是 HPV58（13.62%）和 HPV52（9.15%）。在本研究中，386 例（55.30%）为 ASCUS 患者，11 例（1.58%）为 ASC-H 患者，137 例（19.63%）为 L-SIL 患者，151 例（21.63%）为 H-SIL 患者。细胞学结果为 ASCUS、ASC-H、L-SIL 和 H-SIL 的患者 HPV 感染率分别为 39.12%、54.17%、70.80%和 80.79%。: 总之，本研究首次调查了新疆细胞学异常妇女 HPV 感染和 HPV 基因型分布的流行情况。在新疆人群接种 HPV 疫苗之前，我们的结果可以作为基线数据和验证集，为特定 HPV 型的流行率提供可靠的估计。
