Sankaran K, Berscheid B, Verma V, Zakhary G, Tan L
JPEN J Parenter Enteral Nutr. 1985 Jul-Aug;9(4):439-42. doi: 10.1177/0148607185009004439.
A total of 75 preterm infants with gestation less than 32 wk received total parenteral nutrition (TPN) using Vamin and Aminosyn as protein base lasting more than 20 days. They were monitored for signs of liver dysfunction, cholestatic jaundice, and TPN-induced metabolic bone disease (osteopenia of prematurity). It was observed that severity of TPN-induced cholestasis depends on the duration of TPN and quantity of protein infused. When used as a protein base, Vamin seemed to be superior to Aminosyn. TPN-induced metabolic bone disease was strongly correlated to the duration of TPN. We suggest close monitoring of critically ill preterm infants on TPN for quantity of protein infusate, liver dysfunction, cholestatic jaundice, and TPN-induced metabolic bone disease. Intravenous protein intake should be limited to less than 2.5 g/kg/day in preterm infants with gestation less than 32 wk.
共有75名孕周小于32周的早产儿接受了以凡命和爱咪特为蛋白质来源的全胃肠外营养（TPN），持续时间超过20天。对他们进行了肝功能障碍、胆汁淤积性黄疸和TPN诱导的代谢性骨病（早产儿骨质减少）体征的监测。观察到TPN诱导的胆汁淤积的严重程度取决于TPN的持续时间和输注的蛋白质量。当用作蛋白质来源时，凡命似乎优于爱咪特。TPN诱导的代谢性骨病与TPN的持续时间密切相关。我们建议对接受TPN的危重新生儿密切监测蛋白输注量、肝功能障碍、胆汁淤积性黄疸和TPN诱导的代谢性骨病。孕周小于32周的早产儿静脉蛋白质摄入量应限制在每天2.5 g/kg以下。
