Department of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Canada.
Eur J Clin Microbiol Infect Dis. 2024 Nov;43(11):2239-2244. doi: 10.1007/s10096-024-04947-z. Epub 2024 Sep 17.
This study investigated the molecular characteristics of urinary carbapenemase-producing Klebsiella pneumoniae isolates (n = 194) in Gauteng, South Africa, using simple, cost-effective PCR methodologies. Extensively drug resistant (XDR) ST307 with bla on IncX3 plasmids was endemic in Gauteng community hospitals leaving limited options for treating in- and outpatient urinary tract infections. High-level ceftazidime/avibactam resistance was detected among isolates harbouring bla including bla. These findings highlighted the need for genomic methodologies suitable for lower- and middle-income countries to track XDR clones and plasmids in community hospitals. Such results will aid with treatment and stewardship strategies.
本研究使用简单、经济有效的 PCR 方法，研究了南非豪登省产碳青霉烯酶肺炎克雷伯菌尿分离株（n=194）的分子特征。广泛耐药（XDR）ST307 型携带 bla 的 IncX3 质粒在豪登省社区医院流行，导致治疗住院和门诊尿路感染的选择有限。携带 bla 的分离株中检测到高水平头孢他啶/阿维巴坦耐药，包括 bla。这些发现强调需要适合中低收入国家的基因组方法，以追踪社区医院中的 XDR 克隆和质粒。这些结果将有助于治疗和管理策略。
