Sletten Reidun, Slaaen Marit, Oldervoll Line Merethe, Skjellegrind Håvard Kjesbu, Benth Jūratė Šaltytė, Åstrøm Lennart, Kirkevold Øyvind, Bergh Sverre, Grønberg Bjørn Henning, Rostoft Siri, Bye Asta, Mork Paul Jarle, Christiansen Ola Berger
Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
The Research Center for Age-Related Functional Decline and Disease, Innlandet Hospital Trust, Ottestad, Norway.
J Cancer Surviv. 2024 Sep 17. doi: 10.1007/s11764-024-01670-8.
Information about outcomes of particular relevance to older prostate cancer survivors is limited. This study aimed to compare health, activities of daily living (ADL), and use of health care services between survivors and matched controls.
A single-centre study on men treated for prostate cancer with curative intent at the age ≥ 70 years 2 to 7 years earlier. Controls matched on age and education were drawn (1:3) from the Trøndelag Health Study (HUNT) in Norway. Self-reported general health, independence in ADL and instrumental activities of daily living (IADL), hospital admissions and emergency room visits were compared by estimating non-adjusted and adjusted (age, education, comorbidity, cohabitant status and pack years of smoking) regression models.
The majority of both survivors (N = 233) and controls (N = 699) reported good (58.7% vs. 62.7%) or very good (11.2% vs. 6.8%) health and independence in ADL (95.6% vs. 96.3%) and IADL (82.7% vs. 81.9%). Hospital admission was reported by 17.3% vs. 18.2% and emergency room visit by 23.6% vs. 26.7%. Regression models showed no significant differences between survivors and controls.
Older prostate cancer survivors reported similar health, independence in ADL and use of emergency room and hospital admissions as matched controls.
This study shows that survivors after curatively intended treatment of prostate cancer have as good health as matched controls, indicating that many patients tolerate such treatment well despite being of old age and that current practice for selection of patients offered such treatment is appropriate.
与老年前列腺癌幸存者特别相关的结局信息有限。本研究旨在比较幸存者与匹配对照之间的健康状况、日常生活活动能力（ADL）以及医疗保健服务的使用情况。
一项单中心研究，对象为2至7年前接受了根治性前列腺癌治疗且年龄≥70岁的男性。年龄和教育程度匹配的对照（1:3）取自挪威特隆赫姆郡健康研究（HUNT）。通过估计未调整和调整（年龄、教育程度、合并症、同居状况和吸烟包年数）回归模型，比较自我报告的总体健康状况、ADL和工具性日常生活活动能力（IADL）的独立性、住院次数和急诊就诊次数。
大多数幸存者（N = 233）和对照（N = 699）报告健康状况良好（58.7%对62.7%）或非常好（11.2%对6.8%），ADL（95.6%对96.3%）和IADL（82.7%对81.9%）具有独立性。报告的住院率分别为17.3%对18.2%，急诊就诊率分别为23.6%对26.7%。回归模型显示幸存者和对照之间无显著差异。
老年前列腺癌幸存者报告的健康状况、ADL独立性以及急诊和住院服务的使用情况与匹配对照相似。
本研究表明，接受前列腺癌根治性治疗后的幸存者与匹配对照的健康状况一样好，这表明许多患者尽管年事已高，但对这种治疗耐受性良好，且目前选择接受此类治疗的患者的做法是合适的。
