Li J C, Sun F, Liu T
Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis, Beijing 100044, China.
Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis, Beijing 100044, China Department of Rheumatology and Immunology, Shijiazhuang People's Hospital, Shijiazhuang 050030, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2024 Sep 6;58(9):1341-1347. doi: 10.3760/cma.j.cn112150-20231110-00332.
To explore the distribution of different biomarkers for Behcet's syndrome (BS) and their correlation with distinct clinical phenotypes of BS patients in real-world studies. This study was a retrospective cross-sectional study. A total of 483 patients diagnosed with BS in the Department of Rheumatology and Immunology, Peking University People's Hospital from 2019 to 2022 were enrolled. The baseline information and clinical features of the patients were recorded at their first diagnosis and tested the level of HLA-B51, several auto-antibodies, antistreptolysin-O(ASO), immune globulin, complement in blood serum and interleukin-6 (IL-6). Logistic regression was used to analyze the correlation of biomarkers and phenotypes. Among BS patients, the number of positive cases for HLA-B51, anti-endothelial cell antibody (AECA), antinuclear antibodies (ANA) and ASO was 129, 115, 79 and 54, respectively. The positive rate of other biomarkers was less than 5.0%. About 12.6% of patients with BS had an increased level of IgA (=61), and 10.8% of patients had an increased level of IgG (=52). About 41.0% of patients had increased levels of IL-6 (=198), and 6.4% of patients had decreased levels of IgM (=31). About 11.2% of patients had decreased levels of C3 (=54), and 6.0% of patients had decreased levels of C4 (=29). Elevated IgA was a risk factor for the articular phenotype of BS (=2.652, =0.011). Decreased complement C4 was a risk factor for the neurological phenotype of BS (=3.594, =0.039). Positive ASO was a risk factor for the gastrointestinal phenotype of BS (=2.578, =0.041). Elevated IL-6 was a risk factor for the ocular phenotype of BS (=7.560, =0.016). HLA-B51 and AECA are common biomarkers in BS. Elevated IgA, decreased complement C4, positive ASO, and elevated IL-6 are risk factors for different phenotypes of BS.
在真实世界研究中，探索白塞病（BS）不同生物标志物的分布及其与BS患者不同临床表型的相关性。本研究为回顾性横断面研究。纳入了2019年至2022年在北京大学人民医院风湿免疫科诊断为BS的483例患者。记录患者首次诊断时的基线信息和临床特征，并检测HLA - B51、几种自身抗体、抗链球菌溶血素O（ASO）、免疫球蛋白、血清补体及白细胞介素 - 6（IL - 6）水平。采用逻辑回归分析生物标志物与表型的相关性。在BS患者中，HLA - B51、抗内皮细胞抗体（AECA）、抗核抗体（ANA）及ASO阳性病例数分别为129、115、79和54例。其他生物标志物的阳性率低于5.0%。约12.6%的BS患者IgA水平升高（=61），10.8%的患者IgG水平升高（=52）。约41.0%的患者IL - 6水平升高（=198），6.4%的患者IgM水平降低（=31）。约11.2%的患者C3水平降低（=54），6.0%的患者C4水平降低（=29）。IgA升高是BS关节表型的危险因素（=2.652，=0.011）。补体C4降低是BS神经表型的危险因素（=3.594，=0.039）。ASO阳性是BS胃肠道表型的危险因素（=2.578，=0.041）。IL - 6升高是BS眼部表型的危险因素（=7.560，=0.016）。HLA - B51和AECA是BS常见的生物标志物。IgA升高、补体C4降低、ASO阳性及IL - 6升高是BS不同表型的危险因素。
