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爱尔兰老年成年人的维生素D、牙周炎与牙齿脱落

Vitamin D, periodontitis and tooth loss in older Irish adults.

作者信息

Winning Lewis, Scarlett Siobhan, Crowe Michael, O'Sullivan Michael, Kenny Rose Anne, O'Connell Brian

机构信息

Dublin Dental University Hospital, Trinity College Dublin, DublinD02 F859, Republic of Ireland.

The Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, Dublin, Republic of Ireland.

出版信息

Br J Nutr. 2024 Sep 18;132(4):1-9. doi: 10.1017/S000711452400148X.

Abstract

The aim of this study is to investigate whether 25-hydroxyvitamin D (25(OH)D) is associated with periodontitis and tooth loss in older adults. A total of 2346 adults underwent a detailed dental examination as part of the health assessment of a national population study - The Irish Longitudinal Study of Ageing. 25(OH)D analysis was performed on frozen non-fasting total plasma using LC-MS. The analysis included both multiple logistic regression and multinominal logistic regression to investigate associations between 25(OH)D concentration, periodontitis and tooth loss, adjusting for a range of potential confounders. Results of the analysis found the mean age of participants was 65·3 years (sd 8·2) and 55·3 % of the group were female. Based on the quintile of 25(OH)D concentration, participants in the lowest . highest quintile had an OR of 1·57 (95 % CI 1·16, 2·13; < 0·01) of having periodontitis in the fully adjusted model. For tooth loss, participants in the lowest . highest quintile of 25(OH)D had a RRR of 1·55 (95 % CI 1·12, 2·13; < 0·01) to have 1-19 teeth and a RRR of 1·96 (95 % CI 1·20, 3·21; < 0·01) to be edentulous, relative to those with ≥ 20 teeth in the fully adjusted models. These findings demonstrate that in this cross-sectional study of older men and women from Ireland, 25(OH)D concentration was associated with both periodontitis and tooth loss, independent of other risk factors.

摘要

本研究的目的是调查25-羟基维生素D(25(OH)D)是否与老年人的牙周炎和牙齿脱落有关。作为一项全国性人口研究——爱尔兰老龄化纵向研究健康评估的一部分,共有2346名成年人接受了详细的牙科检查。使用液相色谱-质谱法对冷冻的非空腹全血进行25(OH)D分析。分析包括多元逻辑回归和多项逻辑回归,以研究25(OH)D浓度、牙周炎和牙齿脱落之间的关联,并对一系列潜在混杂因素进行调整。分析结果发现,参与者的平均年龄为65.3岁(标准差8.2),该组中55.3%为女性。根据25(OH)D浓度的五分位数,在完全调整模型中,处于最低……最高五分位数的参与者患牙周炎的比值比为1.57(95%置信区间1.16, 2.13;P<0.01)。对于牙齿脱落,在完全调整模型中,相对于有≥20颗牙齿的参与者,处于25(OH)D最低……最高五分位数的参与者有1-19颗牙齿的相对危险度降低率为1.55(95%置信区间1.12, 2.13;P<0.01),无牙的相对危险度降低率为1.96(95%置信区间1.20, 3.21;P<0.01)。这些发现表明,在这项针对爱尔兰老年男性和女性的横断面研究中,25(OH)D浓度与牙周炎和牙齿脱落均有关联,且独立于其他风险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a532/11499080/5a5016c96a0b/S000711452400148X_fig1.jpg

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