Raychaudhuri Suravi, Dong Zhao Ming, Knowles Scott, Graf Solomon
Fred Hutchinson Cancer Center, Seattle, WA, USA.
VA Puget Sound Health Care System, Seattle, WA, USA.
Case Rep Hematol. 2024 Sep 10;2024:8810646. doi: 10.1155/2024/8810646. eCollection 2024.
EBV-positive primary nodal T-cell/NK cell lymphoma (TNKL) is a rare diagnosis with a poor prognosis. No relationship with follicular lymphoma (FL), classic Hodgkin lymphoma (cHL), or other non-Hodgkin lymphomas is established. We describe a case of Epstein-Barr virus (EBV)-positive cHL and EBV-positive primary nodal TNKL in the background of an antecedent FL, with all 3 subtypes identified in a single lymph node biopsy from an immunocompetent patient. Intensive frontline therapy achieved only a temporary response, with subsequent rapid progression associated with hemophagocytic lymphohistiocytosis (HLH). We discuss the relationship of the three lymphoma subtypes and the potential roles of EBV and immune dysregulation as contributing factors to this previously undescribed composite lymphoma.
EB病毒阳性的原发性淋巴结T细胞/NK细胞淋巴瘤（TNKL）是一种罕见的诊断，预后较差。目前尚未确定其与滤泡性淋巴瘤（FL）、经典型霍奇金淋巴瘤（cHL）或其他非霍奇金淋巴瘤之间的关系。我们描述了一例在先前存在FL的背景下，同时存在爱泼斯坦-巴尔病毒（EBV）阳性的cHL和EBV阳性的原发性淋巴结TNKL的病例，在一名免疫功能正常患者的单次淋巴结活检中发现了所有这3种亚型。强化一线治疗仅取得了暂时缓解，随后迅速进展并伴有噬血细胞性淋巴组织细胞增生症（HLH）。我们讨论了这三种淋巴瘤亚型之间的关系，以及EBV和免疫失调作为促成这一先前未描述的复合淋巴瘤的潜在因素所起的作用。
