评估膜联蛋白家族作为预测肾透明细胞癌进展和预后的潜在生物标志物。

Evaluation of Annexins Family as Potential Biomarker for Predicting Progression and Prognosis in Clear Renal Cell Carcinoma.

作者信息

Zhao Jiyu, Chang Luchen, Tu Jianping, Sun Bei, Wei Xi

机构信息

Department of Urology, ChuiYangLiu Hospital Affiliated to Tsinghua University, 100021 Beijing, China.

Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, 300060 Tianjin, China.

出版信息

Evid Based Complement Alternat Med. 2022 Jun 8;2022:8748434. doi: 10.1155/2022/8748434. eCollection 2022.

DOI:10.1155/2022/8748434

PMID:39290334

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11407897/

Abstract

BACKGROUND

Annexins family (ANXAs), as a Ca-dependent phospholipid-binding protein superfamily, participates in a wide variety of biological activities and has been reported to be dysregulated in numerous types of human cancers. Evidence from cell lines and human tissues indicates that ANAXs are involved in kidney clear renal cell carcinoma (KIRC) tumorigenesis. However, their prognostic value and expression pattern associated with KIRC remain to be elucidated.

METHODS

We visited public databases, including ONCOMINE, Gene Expression Profiling Interactive Analysis (GEPIA), Kaplan-Meier plotter, cBioPortal, and GeneMANIA, to conduct comprehensive bioinformatics analysis and tried to detect basic relationships between each Annexins family member and KIRC.

RESULTS

We found that the expression level of ANXA1/2/4/5/6/7/8/13 in clear renal cell carcinoma tissue was higher than that in the kidney tissue, while the expression level of ANXA3/9/11 in the former was lower than that in the latter. The expression level of ANXA7/8/13 is related to the stage of the tumour. Survival analysis using the Kaplan-Meier plotter database showed that a high transcription level of ANXA2/5/8/10 is related to a low overall survival rate (OS) in predicting KIRC patients. In contrast, high ANXA3/4/7/9/11/13 levels are associated with a high OS in these patients.

CONCLUSIONS

Our study implies that ANXA4/8/13 are potential targets of precision therapy for patients with KIRC and that ANXA2/5/8/10 are new biomarkers for the prognosis of KIRC.

摘要

背景

膜联蛋白家族（ANXAs）作为一种依赖钙离子的磷脂结合蛋白超家族，参与多种生物学活动，且据报道在多种人类癌症中表达失调。来自细胞系和人体组织的证据表明，膜联蛋白参与肾透明细胞癌（KIRC）的肿瘤发生。然而，它们与KIRC相关的预后价值和表达模式仍有待阐明。

方法

我们访问了多个公共数据库，包括ONCOMINE、基因表达谱交互式分析（GEPIA）、Kaplan-Meier绘图仪、cBioPortal和GeneMANIA，以进行全面的生物信息学分析，并试图检测每个膜联蛋白家族成员与KIRC之间的基本关系。

结果

我们发现，肾透明细胞癌组织中ANXA1/2/4/5/6/7/8/13的表达水平高于肾组织，而前者中ANXA3/9/11的表达水平低于后者。ANXA7/8/13的表达水平与肿瘤分期有关。使用Kaplan-Meier绘图仪数据库进行的生存分析表明，在预测KIRC患者时，ANXA2/5/8/10的高转录水平与低总生存率（OS）相关。相反，在这些患者中，高ANXA3/4/7/9/11/13水平与高OS相关。