Roslan Muhamad Naquib Faisal, Naharudin Idanawati, Musa Nafisah, Anuar Nor Khaizan
Jabatan Farmasi Hospital Tengku Ampuan Rahimah, Klang, Selangor, Malaysia.
Faculty of Pharmacy, Universiti Teknologi MARA, Cawangan Selangor, Kampus Puncak Alam, Puncak Alam, Selangor, Malaysia.
J Adv Pharm Technol Res. 2024 Jul-Sep;15(3):139-143. doi: 10.4103/japtr.japtr_538_23. Epub 2024 Jul 22.
Candida species are the primary cause of candidiasis, a common yeast infection, with being the most prevalent pathogen. These infections often infiltrate the body through cutaneous and vaginal routes. Given the potential severity of some Candida infections, particularly invasive cases, there is a critical need for effective antifungal treatments. Controlled drug delivery strategies have been developed to achieve optimal release kinetics and precise targeting of active agents, especially in fungal infection therapeutics. Consequently, significant attention has been focused on exploring and utilizing bioadhesive polymers to enhance the performance of drug delivery systems for antifungal medications. Bioadhesive drug delivery systems aim to sustain the release of therapeutic agents, reducing the need for frequent dosing. This article provides a comprehensive review of scientific investigations into the use of antifungal drugs within bioadhesive drug delivery systems for treating candidiasis, locally and systemically. The evaluation covers the efficacy of these systems against candidiasis, factors affecting prolonged contact at the application site, and the underlying mechanisms of drug delivery.
念珠菌属是念珠菌病（一种常见的酵母菌感染）的主要病因，其中白色念珠菌是最普遍的病原体。这些感染通常通过皮肤和阴道途径侵入人体。鉴于某些念珠菌感染（尤其是侵袭性病例）的潜在严重性，迫切需要有效的抗真菌治疗方法。已经开发出可控药物递送策略，以实现活性剂的最佳释放动力学和精确靶向，特别是在真菌感染治疗中。因此，人们将大量注意力集中在探索和利用生物粘附聚合物来提高抗真菌药物递送系统的性能上。生物粘附药物递送系统旨在持续释放治疗剂，减少频繁给药的需求。本文全面综述了关于在生物粘附药物递送系统中使用抗真菌药物治疗局部和全身性念珠菌病的科学研究。评估内容包括这些系统对念珠菌病的疗效、影响在应用部位延长接触的因素以及药物递送的潜在机制。
