Morsia Serena, Paganelli Alessia, Acciardi Alessandra, Alma Antonio, Bertoli Cristina, Reggiani Camilla, Garbarino Federico, Fiorentini Chiara, Ferrari Barbara, Francomano Mariangela, Magnoni Cristina
Dermatologic Surgery Unit, Modena University Hospital.
Dermatology Unit, Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia Local Health Unit, Italy.
Dermatol Reports. 2024 Feb 15;16(3):9941. doi: 10.4081/dr.2024.9941. eCollection 2024 Sep 2.
Acellular dermal matrices currently represent a useful reconstructive method in onco-dermatologic surgery. Nevertheless, they have some limitations, especially in terms of costs and outpatient post-operative wound care. While some studies on their cost-to-benefit ratio in breast surgery have already been issued, evidence is currently lacking in onco-dermatological surgery. The aim of this study was to evaluate the clinical outcomes perceived by patients who had undergone onco-dermatologic surgery in which either acellular dermal matrices or skin grafts had been used as reconstructive methods. A study population of 150 patients was identified retrospectively and patients' degree of satisfaction was assessed through the Global Aesthetic Improvement Scale and the Patient Scar Scale Questionnaire. Despite similar scores among the study groups, slightly better results were appreciable after single-stage grafting. However, to what extent these variations really represent a significant difference from a clinical point of view remains to be determined. Moreover, other potential bias in the interpretation of our results may reside in differences in terms of age, body location and baseline tumor size among the study groups. Therefore, further research is needed.
脱细胞真皮基质目前是肿瘤皮肤科手术中一种有用的重建方法。然而，它们有一些局限性，特别是在成本和门诊术后伤口护理方面。虽然已经发表了一些关于它们在乳腺手术中的成本效益比的研究，但目前肿瘤皮肤科手术方面缺乏相关证据。本研究的目的是评估接受肿瘤皮肤科手术的患者的临床结果，这些手术中使用脱细胞真皮基质或皮肤移植作为重建方法。回顾性确定了150名患者的研究人群，并通过全球美学改善量表和患者瘢痕量表问卷评估患者的满意度。尽管研究组之间的分数相似，但单阶段移植后可观察到稍好的结果。然而，从临床角度来看，这些差异在多大程度上真正代表显著差异仍有待确定。此外，我们结果解释中的其他潜在偏差可能存在于研究组之间在年龄、身体部位和基线肿瘤大小方面的差异。因此，需要进一步的研究。
