Chen Xiaolong, Li Chun Guang, Zhou Xian, Zhu Minghua, Jin Jing, Wang Ping
School of Physical Education, Hangzhou Normal University, Hangzhou, China.
NICM Health Research Institute, Western Sydney University, Westmead, NSW, Australia.
Front Physiol. 2024 Sep 3;15:1431030. doi: 10.3389/fphys.2024.1431030. eCollection 2024.
Mitochondria and lysosomes play a very important role in maintaining cellular homeostasis, and the dysfunction of these organelles is closely related to many diseases. Recent studies have revealed direct interactions between mitochondria and lysosomes, forming mitochondria-lysosome contact sites that regulate organelle network dynamics and mediate the transport of metabolites between them. Impaired function of these contact sites is not only linked to physiological processes such as glucose and cholesterol transport but also closely related to the pathological processes of metabolic diseases. Here, we highlight the recent progress in understanding the mitochondria-lysosome contact sites, elucidate their role in regulating metabolic homeostasis, and explore the potential implications of this pathway in metabolic disorders.
线粒体和溶酶体在维持细胞内稳态方面发挥着非常重要的作用，这些细胞器的功能障碍与许多疾病密切相关。最近的研究揭示了线粒体和溶酶体之间的直接相互作用，形成了线粒体 - 溶酶体接触位点，这些位点调节细胞器网络动态并介导它们之间代谢物的运输。这些接触位点的功能受损不仅与葡萄糖和胆固醇运输等生理过程有关，还与代谢性疾病的病理过程密切相关。在这里，我们重点介绍了在理解线粒体 - 溶酶体接触位点方面的最新进展，阐明了它们在调节代谢稳态中的作用，并探讨了该途径在代谢紊乱中的潜在影响。
