Shahsavarinia Kavous, Hajipoor Kashgsaray Nasim, Ghojazadeh Morteza, Falaki Zahra, Soleimanpour Maryam, Soleimanpour Hassan
Research Center for Evidence-based Medicine, Iranian EBM Centre: AJBI Centre of Excellence, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Emergency and trauma care research center, Tabriz University of Medical Sciences, Tabriz, Iran.
Arch Acad Emerg Med. 2024 Aug 25;12(1):e65. doi: 10.22037/aaem.v12i1.2385. eCollection 2024.
Acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH) are among the acute cerebrovascular diseases (CVDs) that have been reported as a result of COVID-19. It will be a significant step forward if our research helps improve the compilation and analysis of existing data from other studies.
The study is registered on PROSPERO with an ID of CRD42023464058. It encompasses articles published until December 2023 and involves searching databases such as PubMed, Scopus, Web of Knowledge, Embase, and Cochrane. Additionally, we conducted manual searches in respected publications within this discipline, utilized the Google Scholar search engine, and conducted reference checks, citation checks, and study of gray literature. The publications' reporting quality was assessed using the "Assessment of Multiple Systematic Reviews" (AMSTAR) checklist. The meta-analysis was conducted using Stata software (StataCorp, version 16).
We analyzed the findings of 23 meta-analyses, which included 795 articles and encompassed 5,937 patients who had previously experienced a stroke. The average age of these patients was 62.3 years, and 68.3% were male. The findings indicated that the collective incidence of stroke among individuals with COVID-19 is roughly 1.75% [95% confidence interval (CI): 0.4%-3.03], with 1.59% for ischemic strokes and 0.3% for hemorrhagic strokes. 32.3% (95% CI: 27.8%-36.9%) of COVID-19 patients with stroke passed away, approximately 27% were discharged from the hospital with very mild or no complications, and around 28.1% (95% CI: 14.1%-42.1%) were referred for rehabilitation.
The overall rate of stroke in COVID-19 patients was approximately 1.75%, with a higher incidence in males and those with an average age of 62.3 years. Almost 80% of the strokes were ischemic, and the mortality rate was approximately 32%. Finally, 27% of the patients were discharged without complications, and 28% required rehabilitation.
急性缺血性卒中（AIS）和脑出血（ICH）是已被报道的由新型冠状病毒肺炎（COVID-19）引发的急性脑血管疾病（CVD）。如果我们的研究有助于改进对其他研究现有数据的汇总和分析，这将是向前迈出的重要一步。
该研究已在国际前瞻性系统评价注册库（PROSPERO）注册，注册号为CRD42023464058。研究涵盖截至2023年12月发表的文章，涉及检索多个数据库，如PubMed、Scopus、Web of Knowledge、Embase和Cochrane。此外，我们还在该领域受尊敬的出版物中进行了手动检索，使用了谷歌学术搜索引擎，并进行了参考文献检查、引文检查以及灰色文献研究。使用“多重系统评价评估”（AMSTAR）清单评估出版物的报告质量。使用Stata软件（StataCorp，版本16）进行荟萃分析。
我们分析了23项荟萃分析的结果，这些分析包括795篇文章，涉及5937名既往有卒中病史的患者。这些患者的平均年龄为62.3岁，男性占68.3%。结果表明，COVID-19患者中卒中的总体发病率约为1.75%[95%置信区间（CI）：0.4% - 3.03%]，其中缺血性卒中为1.59%，出血性卒中为0.3%。32.3%（95% CI：27.8% - 36.9%）的COVID-19卒中患者死亡，约27%出院时仅有非常轻微的并发症或无并发症，约28.1%（95% CI：14.1% - 42.1%）被转诊进行康复治疗。
COVID-19患者的总体卒中发生率约为1.75%，男性和平均年龄62.3岁的患者发病率更高。几乎80%的卒中为缺血性，死亡率约为32%。最后，27%的患者出院时无并发症，28%需要康复治疗。
