Choina Magdalena, Kowal Krzysztof, Markut-Miotła Ewa, Majsiak Emilia
Department of Experimental Allergology and Immunology, Medical University of Bialystok, Poland.
Department of Allergology and Internal Medicine, Medical University of Bialystok, Poland.
Postepy Dermatol Alergol. 2024 Aug;41(4):339-349. doi: 10.5114/ada.2024.142390. Epub 2024 Aug 21.
Component-resolved diagnostics enables the detection of allergen-specific immunoglobulins E (asIgE) to house dust mite (HDM) proteins, which may help clinicians to face the difficulties in diagnostics of HDM allergy. Currently, almost 40 proteins of species, that are able to bind asIgE, have been identified, and this number will certainly increase. The association between sensitisation to particular molecules and allergy symptoms is extensively studied. This investigation enables us to identify HDM molecules that promote respiratory, skin, or food allergies, and it could help us predict the possible course of allergic diseases. The individual repertoire of asIgE improves our understanding of immunological response, which underlies allergy symptoms, and helps to form individual therapeutic regimens. This review provides clinicians with information on proteins available in commercial arrays, and their role in the diagnostics and management of HDM allergy.
组分分辨诊断能够检测针对屋尘螨（HDM）蛋白的变应原特异性免疫球蛋白E（asIgE），这可能有助于临床医生应对HDM过敏诊断中的困难。目前，已经鉴定出近40种能够结合asIgE的该物种蛋白，而且这个数量肯定还会增加。对特定分子致敏与过敏症状之间的关联进行了广泛研究。这项研究使我们能够识别出会引发呼吸道、皮肤或食物过敏的HDM分子，并有助于我们预测过敏性疾病可能的病程。asIgE的个体谱有助于我们更好地理解作为过敏症状基础的免疫反应，并有助于制定个体化治疗方案。本综述为临床医生提供了有关商业检测阵列中可用蛋白的信息，以及它们在HDM过敏诊断和管理中的作用。
