M Jegatheeswaran, Khan Mohammad Nezamuddin, R Ajith, Sundararajan Sarumathy, R Nanda Kumar
Department of Pharmacy Practice, SRM (Sri Ramaswamy Memorial) College of Pharmacy, Faculty of Medical and Health Sciences, SRM Institute of Science and Technology, Chengalpattu, IND.
Department of General Medicine, SRM (Sri Ramaswamy Memorial) Medical College Hospital and Research Centre, Chengalpattu, IND.
Cureus. 2024 Aug 18;16(8):e67101. doi: 10.7759/cureus.67101. eCollection 2024 Aug.
Intensive medical care units (IMCUs) usually admit patients who are in critical medical need and require the utmost attention of healthcare professionals, along with the best treatment options available. These patients are prone to infections and require various antibiotics for the treatment. Varying costs of antibiotics, variable dosage forms, and antibiotic resistance cause an economic burden on patients Methodology: This study was designed and conducted prospectively to evaluate the prescribing pattern of antibiotics at the IMCU in a tertiary care hospital. A total of 102 patients were included in the study based on the exclusion and inclusion criteria, and the collected data was tabulated in an Excel sheet and analyzed using Prism GraphPad software. Data were presented as numbers and percentages.
Most of the patients were in the age group of 41-50 years. The number of male patients was slightly more than that of female patients. The majority of the patients admitted to the IMCU had acute pulmonary edema and cerebrovascular accidents. Most antibiotics were prescribed empirically and administered parenterally, of which Amoxicillin + Potassium clavulanate was the most commonly used antibiotic. Tigecycline had the highest daily defined dose per 100 bed days value, and injection Sulbactam + Cefoperazone was the costliest of all antibiotic therapy.
Antibiotic therapy used in the IMCU consisting of Sulbactam + Cefoperazone was found to be costlier, and Amoxicillin + Potassium clavulanate were the commonly prescribed antibiotics among the other prescribed antibiotics. The average cost of antibiotics was found to be higher, which increased the economic healthcare burden for patients and their families.
重症监护病房（IMCUs）通常收治有紧急医疗需求、需要医护人员给予最大程度关注以及接受最佳可用治疗方案的患者。这些患者容易感染，需要使用各种抗生素进行治疗。抗生素成本各异、剂型不同以及抗生素耐药性给患者带来了经济负担。方法：本研究进行了前瞻性设计与实施，以评估一家三级医院重症监护病房的抗生素处方模式。根据排除和纳入标准，共有102例患者纳入研究，收集的数据录入Excel表格，并使用Prism GraphPad软件进行分析。数据以数字和百分比形式呈现。
大多数患者年龄在41 - 50岁之间。男性患者数量略多于女性患者。入住重症监护病房的大多数患者患有急性肺水肿和脑血管意外。大多数抗生素是经验性处方且通过肠胃外给药，其中阿莫西林+克拉维酸钾是最常用的抗生素。替加环素每100床日的限定日剂量值最高，注射用舒巴坦+头孢哌酮是所有抗生素治疗中成本最高的。
在重症监护病房使用的抗生素治疗中，发现舒巴坦+头孢哌酮成本较高；在其他处方抗生素中，阿莫西林+克拉维酸钾是常用的处方抗生素。抗生素的平均成本较高，这增加了患者及其家庭的医疗经济负担。
