Adzahar Sumaiyah, Daud Adibah, Razak Syamihah Mardhiah A, Abdul Jalil Kamariah, Nordin Mohammad Hudzaifah, Mohamad Mustafa Muhammad 'Aqil Nazahah, Mohd Shukri Daniel Hazim, Azhar Azzahra, Syed Abdul Rahman Sharifah Sakinah, Zulkeflee Razan Hayati
Department of Pathology and Medical Laboratory, Faculty of Medicine, Hospital Universiti Sultan Zainal Abidin, Kuala Terengganu, MYS.
Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Terengganu, MYS.
Cureus. 2024 Aug 17;16(8):e67096. doi: 10.7759/cureus.67096. eCollection 2024 Aug.
ABO discrepancies in plasma cell myeloma (PCM) present unique challenges in blood typing tests and transfusion management. We present the case of a 51-year-old male with PCM who exhibited discrepancies between forward and reverse blood grouping. Further investigation revealed that the patient's blood type was a variant of blood group B. While type III discrepancies, typically characterized by elevated globulin levels causing false-positive reactions in both forward and reverse blood grouping, are common in multiple myeloma, our case differed due to the loss of B antigens secondary to the malignant condition. This caused a discrepancy in forward blood grouping. The rarity of ABO discrepancies in multiple myeloma underscores the importance of thorough evaluation. Awareness of potential antigen alterations in such patients is crucial to ensure safe transfusion practices.
浆细胞骨髓瘤（PCM）中的ABO血型不符在血型检测和输血管理中带来了独特的挑战。我们报告了一例51岁患有PCM的男性病例，该患者在正反向血型鉴定中出现不符情况。进一步调查发现，患者的血型是B血型的一种变体。虽然III型不符在多发性骨髓瘤中很常见，其典型特征是球蛋白水平升高导致正反向血型鉴定中出现假阳性反应，但我们的病例有所不同，是由于恶性疾病导致B抗原缺失。这导致了正定型中的血型不符。多发性骨髓瘤中ABO血型不符的罕见性凸显了全面评估的重要性。了解此类患者潜在的抗原改变对于确保安全输血操作至关重要。
