Jiang Mingming, Li Linyun, Liu Hongjie, Xie Hua
Department of Oncology, Xuancheng Hospital Affiliated to Wannan Medical College, Xuancheng, Anhui 242000, P.R. China.
Oncol Lett. 2024 Sep 3;28(5):530. doi: 10.3892/ol.2024.14663. eCollection 2024 Nov.
Breast cancer (BC) remains one of the most common malignant diseases affecting female patients, and it can metastasize to nearly every part of the body. BC is rare in men, and therefore men rarely develop BC liver metastases (BCLMs). However, the present study reports a 55-year-old male patient who underwent surgery 5 years ago for BC. After treatment, the patient was actively followed up regularly. Recently, the patient was examined for chest tightness, and liver space-occupying lesions were found. The upper abdominal enhanced computed tomography images of the patient showed that the liver density was not uniform and that the liver had a mass. A crude needle biopsy was used to examine the liver tumour under the guidance of ultrasound. The pathology revealed that the patient was positive for E-cadherin, oestrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, GATA binding protein 3 and CK7. The patient was subsequently diagnosed with BCLM. The patient was treated with doxorubicin hydrochloride, cyclophosphamide, Docetaxel and followed up regularly. The present case report emphasizes that BC is found not only in women but also in an increasing number of men, and that liver metastasis can occur in males with BC. BCLM is a complex process, and therefore it is hoped this case report will improve the understanding of male BCLM and the mechanism of this disease.
乳腺癌(BC)仍然是影响女性患者的最常见恶性疾病之一,它几乎可以转移至身体的各个部位。BC在男性中较为罕见,因此男性很少发生BC肝转移(BCLMs)。然而,本研究报告了一名55岁的男性患者,他在5年前因BC接受了手术。治疗后,该患者接受了积极的定期随访。最近,该患者因胸闷接受检查,发现肝脏有占位性病变。患者的上腹部增强计算机断层扫描图像显示肝脏密度不均匀且有肿块。在超声引导下使用粗针活检对肝脏肿瘤进行检查。病理结果显示患者的E-钙黏蛋白、雌激素受体、孕激素受体、人表皮生长因子受体2、GATA结合蛋白3和CK7呈阳性。该患者随后被诊断为BCLM。该患者接受了盐酸多柔比星、环磷酰胺、多西他赛治疗并定期随访。本病例报告强调,BC不仅在女性中被发现,而且在越来越多的男性中也有发现,并且男性BC患者可能会发生肝转移。BCLM是一个复杂的过程,因此希望本病例报告能增进对男性BCLM及其发病机制的了解。