Ma Qing, Song Bo, Cao Kun, She Xiaoyun, Chen Wei, Wang Weijun, Huang Huiying
School of Clinical Medicine, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.
Department of Neurology, Meishan City People's Hospital, Meishan, Sichuan 620000, P.R. China.
Oncol Lett. 2024 Sep 3;28(5):532. doi: 10.3892/ol.2024.14665. eCollection 2024 Nov.
Malignant melanoma meningeal metastasis (MMMM) is a rare clinical condition with a poor prognosis. The observation of hemorrhagic cerebrospinal fluid (CSF) in this type of disease is relatively uncommon and may indicate disease progression. The present study reports the case of a 51-year-old male with malignant melanoma who presented with a headache. Imaging studies did not identify abnormalities; however, an analysis of the CSF revealed hemorrhagic changes. The results of cytological examination of the CSF showed melanoma cells, leading to the final diagnosis of MMMM. This case emphasizes the importance of monitoring neurological symptoms and conducting comprehensive CSF cytological examination in patients with melanoma, creating disease awareness in clinicians.
恶性黑色素瘤脑膜转移（MMMM）是一种临床罕见且预后不良的疾病。在这类疾病中观察到出血性脑脊液（CSF）相对少见，可能提示疾病进展。本研究报告了一例51岁男性恶性黑色素瘤患者，其表现为头痛。影像学检查未发现异常；然而，脑脊液分析显示有出血性改变。脑脊液细胞学检查结果显示存在黑色素瘤细胞，最终确诊为MMMM。该病例强调了对黑色素瘤患者监测神经症状并进行全面脑脊液细胞学检查的重要性，提高了临床医生对该疾病的认识。
