Dev Indraja Devidas, Sahay Ayushi, Puranik Ameya D, Purandare Nilendu C, Agrawal Archi, Shah Sneha, Choudhury Sayak, Ghosh Suchismita, Rangarajan Venkatesh
Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital and Advanced Center for Training, Research and Education in Cancer, Tata Memorial Center, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
Department of Pathology, Tata Memorial Center, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
Indian J Nucl Med. 2024 May-Jun;39(3):216-219. doi: 10.4103/ijnm.ijnm_34_24. Epub 2024 Aug 17.
Extracranial metastasis from high-grade glial tumors is an extremely rare condition with its reported incidence being <1%. The most common sites reported in the literature are leptomeninges and spinal cord, followed by the liver, lung, and skeletal system. Its low incidence is thought to be related to the intrinsic aggressive biology of the tumor, thus reducing median overall survival in patients. As there is lack of knowledge about the mechanism of extracranial spread of glioma cells, its diagnosis and management remain a major challenge. We report two cases of extracranial metastases from glial tumors to cervical nodes and postoperative site involving preauricular region detected on F18 Fluoro ethyl tyrosine (FET) positron emission tomography-computed tomography and later on confirmed with histopathology Fluoro ethyl tyrosine.
高级别胶质瘤的颅外转移是一种极其罕见的情况，据报道其发生率<1%。文献中报道的最常见部位是软脑膜和脊髓，其次是肝脏、肺和骨骼系统。其低发生率被认为与肿瘤固有的侵袭性生物学特性有关，从而降低了患者的中位总生存期。由于对胶质瘤细胞颅外扩散机制缺乏了解，其诊断和治疗仍然是一项重大挑战。我们报告了两例胶质瘤颅外转移至颈部淋巴结及术后部位累及耳前区域的病例，这些病例在F18氟代乙基酪氨酸（FET）正电子发射断层扫描-计算机断层扫描上被检测到，随后经组织病理学氟代乙基酪氨酸证实。
