Post Graduate student, Department of Periodontics and Implantology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, 442001, India.
Professor and Head of the Department, Department of Periodontics and Implantology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, 442001, India.
F1000Res. 2024 May 24;12:393. doi: 10.12688/f1000research.131461.2. eCollection 2023.
Periodontal regeneration therapies frequently involve autologous platelet concentrates (APCs). They can be used in sinus lift surgeries and socket preservation, among other clinical settings. Platelet rich fibrin (PRF) membrane has been used to treat gingival recession in individuals or groups of individuals using a coronally progressed or lateral pedicle flap. In the treatment of mixed periodontic endodontic lesion/furcation defect, PRF functions as a healing and interpositional biomaterial, filling a cystic cavity. PRF is known to help the bone regeneration process. In the last few years, efforts have been made to enhance the PRFs characteristics and quality. One of them is titanium platelet rich fibrin (T-PRF). Third-generation platelet concentrate no longer contains silica, and its preparation in glass vacuum containers, that no longer creates any known concerns. The effectiveness PRF's has been evaluated in connective tissue and bone repair. The aim of this study is to compare T-PRF to other platelet concentrates and different treatment modalities for periodontal regenerative procedures.
A protocol of this systematic review have been registered in prospero (CRD42022293545). The online database searched were PUBMED, COCHRANE for published articles up to November 2022 without language restrictions. Studies in trial registers, handsearching, bibliographic references of relevant articles were also checked. Data collection and analysis was done by individual authors. Independent eligibility assessments were conducted by four review authors. Then, using the standard Cochrane methodology, four review authors extracted the data and evaluated the risk of bias for individual studies. We developed "Summary of findings" tables and used GRADE to evaluate the evidence.
Three studies were included for meta-analysis. Results of meta-analysis supported that T-PRF is effective for correction of both hard and soft tissue defects.
The overall qualitative and quantitative analysis suggest that T-PRF has superior structural properties and thicker fibrin network for ensuring predictable success periodontal regenerative procedures.
牙周再生疗法常涉及自体血小板浓缩物（APCs）。它们可用于鼻窦提升手术和牙槽窝保存等临床环境。富血小板纤维蛋白（PRF）膜已用于治疗个体或个体群体的牙龈退缩，使用冠向推进或侧向蒂瓣。在治疗混合牙周牙髓病变/分叉缺损时，PRF 作为一种愈合和间充质生物材料，填充囊性腔。已知 PRF 有助于骨再生过程。在过去几年中，人们努力增强 PRF 的特性和质量。其中之一是钛富血小板纤维蛋白（T-PRF）。第三代血小板浓缩物不再含有二氧化硅，其在玻璃真空容器中的制备不再产生任何已知问题。PRF 的有效性已在结缔组织和骨修复中得到评估。本研究旨在比较 T-PRF 与其他血小板浓缩物和不同的牙周再生治疗方法。
本系统评价的方案已在 prospero（CRD42022293545）中注册。在线数据库搜索包括 PUBMED、COCHRANE，检索截至 2022 年 11 月的已发表文章，无语言限制。还检查了试验登记处的研究、手工搜索、相关文章的参考文献。数据收集和分析由作者个人进行。四名审查员独立进行资格评估。然后，使用标准的 Cochrane 方法，四名审查员提取数据并评估单个研究的偏倚风险。我们制定了“研究结果总结”表，并使用 GRADE 评估证据。
纳入了三项研究进行荟萃分析。荟萃分析的结果支持 T-PRF 对硬组织和软组织缺陷的矫正均有效。
总体定性和定量分析表明，T-PRF 具有更好的结构特性和更厚的纤维蛋白网络，可确保牙周再生治疗的可预测成功。
