PhD Researcher - University of Medicine and Pharmacy Craiova, str. Petru Rares no.2, 200349, Craiova, Romania.
Varinor Matériaux SA, 7 St-Georges str, CH 2800, Delémont, Switzerland.
Medicina (Kaunas). 2019 May 15;55(5):141. doi: 10.3390/medicina55050141.
New therapies that accelerate musculoskeletal tissue recovery are highly desirable. Platelet-rich fibrin (PRF) is a leukocyte- and platelet-rich fibrin biomaterial that acts as a binding site for both platelets and growth factors. Through increasing the local concentration of growth factors at specific tissues, PRF promotes tissue regeneration. PRF has been frequently used in combination with bone graft materials to reduce healing times and promote bone regeneration during maxillofacial surgery. However, its benefits during muscle repair and recovery are less well-documented. Here, we perform a narrative review on PRF therapies and muscle injuries to ascertain its beneficial effects. We reviewed the factors that contribute to the biological activity of PRF and the published pre-clinical and clinical evidence to support its emerging use in musculoskeletal therapy. We include in vitro studies, in vivo animal studies and clinical articles highlighting both the success and failures of PRF treatment. PRF can promote the healing process when used in a range of orthopaedic and sports-related injuries. These include cartilage repair, rotator cuff surgery and anterior cruciate ligament surgery. However, conflicting data for these benefits have been reported, most likely due to inconsistencies in both PRF preparation protocols and dosing regimens. Despite this, the literature generally supports the use of PRF as a beneficial adjuvant for a range of chronic muscle, tendon, bone or other soft tissue injuries. Further clinical trials to confirm these benefits require consistency in PRF preparation and the classification of a successful clinical outcome to fully harness its potential.
新的加速肌肉骨骼组织恢复的治疗方法是非常需要的。富含血小板纤维蛋白（PRF）是一种富含白细胞和血小板的纤维蛋白生物材料，可作为血小板和生长因子的结合位点。通过增加特定组织中生长因子的局部浓度，PRF 促进组织再生。PRF 已被频繁用于与骨移植物材料联合使用，以减少颌面外科手术中的愈合时间并促进骨再生。然而，其在肌肉修复和恢复中的益处记录较少。在这里，我们对 PRF 治疗和肌肉损伤进行了叙述性综述，以确定其有益效果。我们回顾了促成 PRF 生物学活性的因素，以及支持其在肌肉骨骼治疗中新兴应用的已发表的临床前和临床证据。我们包括体外研究、体内动物研究和临床文章，突出了 PRF 治疗的成功和失败。PRF 可在一系列骨科和与运动相关的损伤中促进愈合过程。这些损伤包括软骨修复、肩袖手术和前交叉韧带手术。然而，这些益处的报告存在矛盾数据，这很可能是由于 PRF 制备方案和剂量方案的不一致。尽管如此，文献普遍支持将 PRF 用作一系列慢性肌肉、肌腱、骨骼或其他软组织损伤的有益辅助剂。需要一致性的 PRF 制备和成功的临床结果分类来进一步临床试验来确认这些益处，以充分发挥其潜力。
