Xu Yi, Fei Xiangyong
Pediatric Department, Dongyang People's Hospital, Dongyang, 322100, China.
Pharmacy Department, Huai'an Hongze District People's Hospital, Huai'an, 223100, China.
Open Med (Wars). 2024 Sep 6;19(1):20240987. doi: 10.1515/med-2024-0987. eCollection 2024.
To explore the relationship between cytokines such as interferon γ (IFN-γ), interleukin-10 (IL-10), and interleukin-6 (IL-6), as well as the severity of the condition, and serum zinc (Zn) and Fe levels in children with infection.
A simple random sampling method was used to select 108 children with infection admitted to the hospital from January to December 2022 as the study subjects. Collect demographic data such as gender, age, and course of disease from all patients, as well as inflammatory cytokines (InCs) such as IFN-γ, IL-10, and IL-6, the severity of the condition, and serum trace element information such as Zn, Fe, calcium (Ca), and potassium (K) from all patients. Spearman correlation analysis was used to examine the relationship between IFN-γ, IL-10, IL-6, severity of illness, and Zn, Fe, Ca, K in children infected with . Additionally, receiver operating characteristic (ROC) curve analysis was used to test the predictive efficacy of Zn, Fe, Ca, and K on the severity of the patient's condition.
This study included 108 children infected with , of whom 6 had clinical data missing >10% and were all excluded. Finally, 102 complete clinical data were collected, with a data recovery efficiency of 94.44%. The differences in IFN-γ, IL-10, IL-6 levels, severity of the condition, as well as Zn, Fe, Ca, K levels among children of different ages, disease courses, body mass, and body temperature showed < 0. 05. Spearman correlation analysis showed that the levels of IFN-γ, IL-10, IL-6, and severity of the condition in children with infection were negatively correlated with Zn, Fe, Ca, and K ( = -0.319 to -0.827, < 0.05). The ROC curve analysis results indicate that Zn, Fe, Ca, and K can all be used as indicators to predict the severity of the patient's condition (AUC = 0.710-0.759, < 0.05).
There is a close relationship between InCs and the severity of the condition in children with and serum trace elements. Therefore, clinical attention should be paid to monitoring the serum trace element levels of children, and reasonable measures should be taken to regulate them to accelerate the progress of disease treatment.
探讨干扰素γ（IFN-γ）、白细胞介素-10（IL-10）、白细胞介素-6（IL-6）等细胞因子与感染患儿病情严重程度以及血清锌（Zn）和铁（Fe）水平之间的关系。
采用简单随机抽样法，选取2022年1月至12月期间收治的108例感染患儿作为研究对象。收集所有患者的性别、年龄、病程等人口学资料，以及IFN-γ、IL-10、IL-6等炎性细胞因子（InCs）、病情严重程度和血清锌、铁、钙（Ca）、钾（K）等微量元素信息。采用Spearman相关性分析，检验感染患儿中IFN-γ、IL-10、IL-6、病情严重程度与锌、铁、钙、钾之间的关系。此外，采用受试者工作特征（ROC）曲线分析，检验锌、铁、钙、钾对患者病情严重程度的预测效能。
本研究纳入108例感染患儿，其中6例临床资料缺失>10%，均被排除。最终收集到102份完整的临床资料，数据回收率为94.44%。不同年龄、病程、体重和体温的患儿在IFN-γ、IL-10、IL-6水平、病情严重程度以及锌、铁、钙、钾水平方面的差异均显示P<0.05。Spearman相关性分析显示，感染患儿的IFN-γ、IL-10、IL-6水平及病情严重程度与锌、铁、钙、钾呈负相关（r=-0.319至-0.827，P<0.05）。ROC曲线分析结果表明，锌、铁、钙、钾均可作为预测患者病情严重程度的指标（AUC=0.710-0.759，P<0.05）。
感染患儿的InCs、病情严重程度与血清微量元素之间存在密切关系。因此，临床应重视监测患儿血清微量元素水平，并采取合理措施进行调节，以加快疾病治疗进程。
