Liao Hsiu-Jung, Chen Hui-Ting, Chang Chih-Hung
Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei.
Department of Medical Research, Far Eastern Memorial Hospital, New Taipei City.
Cartilage. 2024 Sep 18:19476035241276406. doi: 10.1177/19476035241276406.
Osteoarthritis (OA) is a widespread degenerative joint condition commonly occurring in older adults. Currently, no disease-modifying drugs are available, and safety concerns associated with commonly used traditional medications have been identified. In this review, a significant portion of research in this field is concentrated on cartilage, aiming to discover methods to halt cartilage breakdown or facilitate cartilage repair.
Researchers have mainly investigated the cartilage, seeking methods to promote its repair. This review focuses on peptide-based molecules known for their ability to selectively bind to growth factor cytokines and components of the cartilage extracellular matrix.
Chondroinductive peptides, synthetically producible, boast superior reproducibility, stability, modifiability, and yield efficiency over natural biomaterials. This review outlines a chondroinductive peptide design, molecular mechanisms, and their application in cartilage tissue engineering and also compares their efficacy in chondrogenesis and .
In this paper, we will summarize the application of peptides engineered to regenerate cartilage by acting as scaffolds, functional molecules, or both and discuss additional possibilities for peptides. This review article provides an overview of our current understanding of chondroinductive peptides for treating OA-affected cartilage and explores the delivery systems used for regeneration. These advancements may hold promise for enhancing or even replacing current treatment methodologies.
骨关节炎（OA）是一种常见于老年人的广泛存在的退行性关节疾病。目前，尚无改善病情的药物，且已发现常用传统药物存在安全问题。在本综述中，该领域的大部分研究都集中在软骨上，旨在发现阻止软骨分解或促进软骨修复的方法。
研究人员主要对软骨进行了研究，寻找促进其修复的方法。本综述重点关注基于肽的分子，这些分子以能够选择性结合生长因子细胞因子和软骨细胞外基质成分而闻名。
可合成生产的软骨诱导肽在可重复性、稳定性、可修饰性和产量效率方面优于天然生物材料。本综述概述了软骨诱导肽的设计、分子机制及其在软骨组织工程中的应用，并比较了它们在软骨生成中的功效。
在本文中，我们将总结经工程改造后可作为支架、功能分子或兼具二者功能来再生软骨的肽的应用，并讨论肽的其他可能性。这篇综述文章概述了我们目前对用于治疗骨关节炎影响的软骨的软骨诱导肽的理解，并探讨了用于再生的递送系统。这些进展可能有望增强甚至取代当前的治疗方法。
