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萘球中毒致严重高铁血红蛋白血症行血浆置换治疗 1 例报告

Plasmapheresis in Severe Methemoglobinemia Following Naphthalene Ball Poisoning: A Case Report.

机构信息

Assistant Professor, Department of General Medicine, S Nijalingappa Medical College and Hanagal Shri Kumareshwar Hospital and Research Centre, Bagalkot, Karnataka, India.

Associate Professor, Department of General Medicine, S Nijalingappa Medical College and Hanagal Shri Kumareshwar Hospital and Research Centre, Bagalkot, Karnataka, India.

出版信息

J Assoc Physicians India. 2024 Sep;72(9):104-105. doi: 10.59556/japi.72.0624.

DOI:10.59556/japi.72.0624
PMID:39291529
Abstract

Naphthalene is a widely used industrial and household chemical in the form of mothballs, but it has rarely been an agent of poisoning worldwide. We describe a case of ingestional naphthalene poisoning with a good outcome after proper management. A 20-year-old boy with a history of seizure disorder and mental retardation presented with abdominal pain, vomiting, burning micturition, and blood in the urine for 2-3 days. On examination, it was found that he had ingested six to eight mothballs and presented 2 days later with hemolysis and methemoglobinemia. He was given intravenous methylene blue, N-acetylcysteine, and ascorbic acid, besides supportive treatment, but the condition did not improve. The patient then underwent plasmapheresis. After two sessions, he showed improvement in the form of decreasing hemolysis. Renal replacement therapy in the form of hemodialysis was performed. Gradually, his condition improved, and concurrent psychiatric assessment and treatment were also provided. The patient was discharged after 15 days.

摘要

萘是一种广泛应用于卫生球等形式的工业和家庭用化学品,但在全球范围内,它很少作为中毒的原因。我们描述了一例摄入萘中毒的病例,经过适当的治疗,患者的结局良好。一名 20 岁的男孩,有癫痫发作和智力障碍病史,出现腹痛、呕吐、尿痛和血尿 2-3 天。体格检查发现他摄入了六到八个卫生球,2 天后出现溶血性贫血和高铁血红蛋白血症。他接受了静脉注射亚甲蓝、N-乙酰半胱氨酸和维生素 C 治疗,以及支持治疗,但病情没有改善。随后患者接受了血浆置换。经过两次治疗,他的溶血情况有所改善。进行了血液透析的肾脏替代治疗。病情逐渐好转,同时进行了精神科评估和治疗。患者在 15 天后出院。

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