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撤回声明:Bcr-Abl/c-Abl合成的反义抑制促进人白血病细胞中的端粒酶活性并上调端锚聚合酶

RETRACTION: Antisense inhibition of Bcr-Abl/c-Abl synthesis promotes telomerase activity and upregulates tankyrase in human leukemia cells.

出版信息

FEBS Lett. 2024 Oct;598(19):2463. doi: 10.1002/1873-3468.15022. Epub 2024 Sep 18.

Abstract

R. Bakalova, H. Ohba, Z. Zhelev, T. Kubo, M. Fujii, M. Ishikawa, Y. Shinohara, and Y. Baba, 'Antisense inhibition of Bcr-Abl/c-Abl synthesis promotes telomerase activity and upregulates tankyrase in human leukemia cells,' FEBS Letters 564, no. 1-2 (2004): 73-84, https://doi.org/10.1016/S0014-5793(04)00318-7. The above article, published online on 9 April 2004 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors; the journal Editor-in-Chief, Michael Brunner; FEBS Press; the National Institute of Advanced Industrial Science and Technology (AIST); and John Wiley and Sons Ltd. Following publication, concerns were raised by a third-party regarding several figures in the article. The subsequent institutional investigation conducted by the AIST revealed: Inappropriate duplication of image panels within the article, between the β-actin loading controls for 4 and 6 days in the Western blot of Fig. 2A K-562; between the subpanels of the electrophoresis blots in Fig. 4A K-562 and Jurkat cells; and between the subpanels of the electrophoresis blots in Fig. 6B. Band insertion in the Western blot of Fig. 6A p210 Bcr-Ab lane. Inappropriate duplication of images between this article (Fig. 2A K562 β-actin and Fig. 4B K562 6 days treatment bands) and an earlier publication from 2003 by an overlapping group of authors representing different experimental conditions. Inappropriate duplication and modification of an image between this article (Figure 3A2) and an earlier publication from 2004 by an overlapping group of authors representing different experimental conditions. Therefore, the conclusions of the paper are substantially compromised and the institute has recommended the paper to be retracted. The editors of the journal agree with the retraction based on the institutional investigation.

摘要

R. 巴卡洛娃、H. 大场、Z. 哲列夫、T. 久保、M. 藤井、M. 石川、Y. 筱原和Y. 马场,“反义抑制Bcr-Abl/c-Abl合成促进人白血病细胞中的端粒酶活性并上调端锚聚合酶”,《欧洲生物化学学会联合会快报》564卷,第1 - 2期(2004年):73 - 84页,https://doi.org/10.1016/S0014-5793(04)00318-7。上述文章于2004年4月9日在威利在线图书馆(wileyonlinelibrary.com)在线发表,已根据作者、期刊主编迈克尔·布鲁纳、欧洲生物化学学会联合会出版社、日本国立先进工业科学技术研究所(AIST)以及约翰·威利父子有限公司之间的协议撤回。文章发表后,第三方对文中的几幅图提出了质疑。随后AIST进行的机构调查发现:文章内图像板块存在不当重复,如在图2A K - 562的蛋白质免疫印迹中4天和6天的β-肌动蛋白上样对照之间;图4A K - 562和Jurkat细胞的电泳印迹子板块之间;以及图6B的电泳印迹子板块之间。图6A p210 Bcr-Ab泳道的蛋白质免疫印迹中存在条带插入。本文(图2A K562β-肌动蛋白和图4B K562 6天处理条带)与2003年由一组重叠作者发表的、代表不同实验条件的早期出版物之间存在图像不当重复。本文(图3A2)与代表不同实验条件的一组重叠作者于2004年发表的早期出版物之间存在图像不当重复和修改。因此,该论文的结论受到严重影响,该研究所建议撤回该论文。期刊编辑基于机构调查结果同意撤回该论文。

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