Nickell S P, Hoff R, Boyer M H
Parasite Immunol. 1985 Jul;7(4):377-86. doi: 10.1111/j.1365-3024.1985.tb00084.x.
We previously observed that mice bearing the autoimmune associated lpr gene exhibit increased susceptibility to challenge with Trypanosoma cruzi, the causative agent of Chagas' disease. We have now tested two other autoimmune prone strains of mice, BXSB and NZB, and found that these animals also show increased sensitivity to acute T. cruzi infection. When challenged with a standard dose (10(2)) of Y strain trypomastigotes, BXSB males (BXSB-YSB), which develop early onset autoimmune disease, suffered high mortality, while late onset autoimmune BXSB females and minimally autoimmune male BXSB mice whose Y chromosome was derived from C57BL/6J mice (BXSB-YB/6) also recover. NZB mice were found to be highly susceptible to challenge while NZW and NZB/W were resistant. A finding common to all groups of susceptible autoimmune mice was increased plasma levels of T. cruzi specific antibody, especially IgM. The data indicate that in two of the three autoimmune prone strains examined, increased T. cruzi susceptibility appears to be linked to restricted genetic elements (i.e. lpr gene and the YSB associated factor) which also influence the rapidity of onset of autoimmunity.
我们之前观察到，携带与自身免疫相关的lpr基因的小鼠对恰加斯病病原体克氏锥虫的攻击表现出更高的易感性。我们现在测试了另外两种易患自身免疫病的小鼠品系，BXSB和NZB，发现这些动物对急性克氏锥虫感染也表现出更高的敏感性。当用标准剂量（10²）的Y株锥鞭毛体进行攻击时，会早发自身免疫病的BXSB雄性小鼠（BXSB-YSB）死亡率很高，而晚发自身免疫病的BXSB雌性小鼠以及Y染色体来自C57BL/6J小鼠的轻度自身免疫的雄性BXSB小鼠（BXSB-YB/6）也能恢复。发现NZB小鼠对攻击高度易感，而NZW和NZB/W则具有抗性。所有易患自身免疫病的易感小鼠组的一个共同发现是，克氏锥虫特异性抗体的血浆水平升高，尤其是IgM。数据表明，在所检测的三个易患自身免疫病的品系中的两个品系中，克氏锥虫易感性增加似乎与也影响自身免疫发病速度的受限遗传元件（即lpr基因和YSB相关因子）有关。
