Boyer M H, Hoff R, Kipnis T L, Murphy E D, Roths J B
Parasite Immunol. 1983 Mar;5(2):135-42. doi: 10.1111/j.1365-3024.1983.tb00731.x.
There is evidence that autoimmune aberrations may contribute to the immunopathological consequences of Chagas' disease and because of this we sought to determine whether four inbred strains of mice bearing the single autosomal recessive gene, lpr (lymphoproliferation), which controls certain autoimmune manifestations, are particularly susceptible to acute infection with the Y strain of Trypanosoma cruzi. MRL/MpJ-lpr/lpr, C57Bl/6J-lpr/lpr, AKR/J-lpr/lpr, C3H/HeJ-lpr/lpr showed parasitaemias 2-10 times higher when compared to their congenic partners. Mortality was significantly higher in three of the four lpr strains. The results indicate that a single autosomal recessive gene which is associated with autoimmunity can influence susceptibility to acute T. cruzi infection in mice.
有证据表明自身免疫异常可能导致恰加斯病的免疫病理后果，因此我们试图确定携带控制某些自身免疫表现的单常染色体隐性基因lpr（淋巴细胞增殖）的四种近交系小鼠是否对克氏锥虫Y株的急性感染特别易感。与它们的同源对照相比，MRL/MpJ-lpr/lpr、C57Bl/6J-lpr/lpr、AKR/J-lpr/lpr、C3H/HeJ-lpr/lpr的虫血症高2至10倍。四个lpr品系中的三个死亡率显著更高。结果表明，与自身免疫相关的单个常染色体隐性基因可影响小鼠对急性克氏锥虫感染的易感性。
