Trucco O, Prado V, Garreaud C, Paya E
Unidad de Microbiología, Facultad de Medicina, Universidad de Chile (Campus Oriente), Santiago.
Rev Med Chil. 1993 Aug;121(8):916-22.
The aim of this study was to compare in vitro activity, measuring minimal inhibitory concentration, of amoxicillin or its combination with clavulanic acid against 109 strains of Acinetobacter baumanii, 104 strains of Hemophilus influenzae and 94 strains of Staphylococcus aureus. All these were obtained from different hospitals of the Santiago Metropolitan Region. Amoxicillin-clavulanic acid association did not improve the activity of amoxicillin against Acinetobacter. The association was not active against methicillin resistant strains of S aureus; instead, it significantly increased the activity of amoxicillin against methicillin susceptible strains. All the H influenzae strains were susceptible to the combination.
本研究旨在比较阿莫西林或其与克拉维酸联合使用对109株鲍曼不动杆菌、104株流感嗜血杆菌和94株金黄色葡萄球菌的体外活性（通过测定最低抑菌浓度）。所有菌株均取自圣地亚哥首都大区的不同医院。阿莫西林 - 克拉维酸联合用药并未提高阿莫西林对鲍曼不动杆菌的活性。该联合用药对耐甲氧西林金黄色葡萄球菌菌株无活性；相反，它显著提高了阿莫西林对甲氧西林敏感菌株的活性。所有流感嗜血杆菌菌株对该联合用药均敏感。
