Tomimoto Masako, Tanimura Kenji, Masuko Naohisa, Uchida Akiko, Imafuku Hitomi, Deguchi Masashi, Yamamoto Akane, Hirota Yushi, Ogawa Wataru, Terai Yoshito
Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan.
Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
J Diabetes Investig. 2024 Dec;15(12):1797-1802. doi: 10.1111/jdi.14310. Epub 2024 Sep 18.
AIMS/INTRODUCTION: This study aimed to evaluate the problems in screening for gestational diabetes mellitus (GDM) by casual blood glucose (CBG) measurements at 24-28 gestational weeks.
Overall, 763 pregnant women who underwent the 50-g glucose challenge test (GCT) at 24-28 gestational weeks were enrolled. The preload blood glucose (0-h BG) level of 50-g GCT was considered as CBG.
A total of 240 women with BG levels at 1-h after loading (1-h BG) on 50-g GCT ≥140 mg/dL underwent the 75-g oral glucose tolerance test, and 98 (40.8%) were diagnosed with GDM. Of the 99 women with GDM, 71 (71.7%) had 0-h BG on 50-g GCT <100 mg/dL.
This study, where pregnant women underwent both CBG and 50-g GCT simultaneously, showed that when CBG at 24-28 gestational weeks ≥100 mg/dL alone was used for screening GDM, many pregnant women with GDM were overlooked.
目的/引言：本研究旨在评估孕24 - 28周时通过测定随机血糖（CBG）筛查妊娠期糖尿病（GDM）存在的问题。
总共纳入了763例在孕24 - 28周接受50克葡萄糖耐量试验（GCT）的孕妇。50克GCT的负荷前血糖（0小时血糖，0-h BG）水平被视为CBG。
共有240例50克GCT负荷后1小时血糖（1小时血糖，1-h BG）水平≥140毫克/分升的女性接受了75克口服葡萄糖耐量试验，其中98例（40.8%）被诊断为GDM。在99例GDM女性中，71例（71.7%）50克GCT的0小时血糖<100毫克/分升。
本研究中孕妇同时进行了CBG和50克GCT检测，结果表明，仅将孕24 - 28周时CBG≥100毫克/分升用于GDM筛查时，许多GDM孕妇会被漏诊。
