Khan Siddique, Baire Beeraiah
Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, Tamil Nadu, India.
Org Lett. 2024 Sep 27;26(38):8165-8170. doi: 10.1021/acs.orglett.4c03061. Epub 2024 Sep 18.
Here we demonstrate the hydrohalogenation reactions of HDDA benzynes promoted by BiX reagents for the generation of complex aryl halides. All three bismuth(III) halides can act as the source for their respective halides, i.e., Cl or Br or I. The regiochemical preference for hydrohalogenation is dependent on the nature of the substituent present at the diyne terminus but neither on the linker nor on the BiX reagent. The substrate scope for this transformation is broad in terms of the tethers A-B-C and the substituents R and R.
在此，我们展示了由BiX试剂促进的HDDA苯炔的氢卤化反应，用于生成复杂的芳基卤化物。所有三种卤化铋（III）都可以作为其各自卤化物（即Cl或Br或I）的来源。氢卤化的区域化学偏好取决于二炔末端存在的取代基的性质，而既不取决于连接基，也不取决于BiX试剂。就连接链A-B-C以及取代基R和R而言，这种转化的底物范围很广。
