Fredericks C M, Ashton S H, Anderson W F, Mathur R S, Lundquist L E, Landgrebe S
Peptides. 1985 Mar-Apr;6(2):205-10. doi: 10.1016/0196-9781(85)90041-5.
Recent experiments conducted in this laboratory have shown that intravenous infusions of vasoactive intestinal polypeptide (VIP) induced significant increases in plasma progesterone (P) in female rabbits. The purpose of this study was to determine the organ source of this P and to clarify the mechanisms by which it is induced. Intravenous infusions of VIP (37.5, 75, and 150 pmol/kg per min for 60 min) produced acute dose-dependent increases in plasma P in intact estrous rabbits. In ovariectomized (OVX) animals, VIP infusion (75 pmol/kg per min) produced a P increase of the same magnitude. In animals both OVX and adrenalectomized (ADX), this VIP effect was eliminated. The only significant change noted in luteotropic hormone (LH) or follicle stimulating hormone (FSH) was a decrease in FSH immediately following VIP infusion (150 pmol/kg). VIP infusion significantly increased plasma cortisol in intact and OVX animals, but not in OVX/ADX animals. It is concluded that VIP primarily stimulates the adrenal component of P secretion in the rabbit, via mechanisms independent of LH or FSH.
本实验室最近进行的实验表明，静脉输注血管活性肠肽（VIP）可使雌性兔血浆孕酮（P）显著升高。本研究的目的是确定这种孕酮的器官来源，并阐明其诱导机制。对处于发情期的完整雌性兔静脉输注VIP（37.5、75和150 pmol/kg每分钟，持续60分钟）可使血浆孕酮呈急性剂量依赖性升高。在去卵巢（OVX）动物中，输注VIP（75 pmol/kg每分钟）可使孕酮升高幅度相同。在既去卵巢又去肾上腺（ADX）的动物中，这种VIP效应消失。在促黄体生成素（LH）或促卵泡生成素（FSH）方面唯一显著的变化是在输注VIP（150 pmol/kg）后FSH立即下降。输注VIP可使完整动物和去卵巢动物的血浆皮质醇显著升高，但在去卵巢/去肾上腺动物中则不然。得出的结论是，VIP主要通过独立于LH或FSH的机制刺激兔体内孕酮分泌的肾上腺成分。
