Neuro-Ophthalmology Unit, Ophthalmology Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Department of General Surgery, Specialized Medical Center, Riyadh, Saudi Arabia.
J Fr Ophtalmol. 2024 Nov;47(9):104137. doi: 10.1016/j.jfo.2024.104137. Epub 2024 Sep 17.
Visual and motility disorders have been reported in cases of syndromic and non-syndromic craniosynostosis. However, to the best of our knowledge, no regional or local studies have addressed the prevalence of ocular manifestations in craniosynostosis among Middle Eastern populations. The purpose of this study was to describe the frequency and nature of ophthalmic abnormalities in Arab children with craniosynostosis and to evaluate these findings pre- and post-craniofacial surgery.
A prospective cohort study of 31 children with craniosynostosis. Demographic information was gathered along with genetic results and ophthalmic evaluations, including cycloplegic refraction.
Age at presentation to the ophthalmology service ranged from 14 months to 8 years, with a median of 3 years. Sixteen patients were female (52%), and 24 patients had undergone a cycloplegic refraction. Of these, 20.8% had significant refractive errors; of those with refractive errors, 40% were myopic and 60% were hyperopic. Eight patients (25.8%) had papilledema, with significant improvement after craniofacial surgery. Five patients (16%) had visual acuity≤20/30 in at least one eye at baseline with improvements in follow-up visits.
Craniosynostosis has a significant impact on visual function in the Arab population. Potentially correctable cases of visual impairment, such as those caused by amblyogenic refractive error and papilledema, are commonly encountered; therefore, timely referral and regular ophthalmic evaluation are recommended for these patients.
在综合征型和非综合征型颅缝早闭病例中已报道存在视觉和运动障碍。然而，据我们所知，尚无区域性或地方性研究针对中东人群颅缝早闭的眼部表现患病率进行探讨。本研究旨在描述阿拉伯裔颅缝早闭儿童眼部异常的发生率和性质，并评估这些发现在颅颌面手术前后的情况。
这是一项对 31 名颅缝早闭儿童进行的前瞻性队列研究。收集了人口统计学信息、基因结果和眼科评估，包括睫状肌麻痹验光。
眼科就诊的年龄范围为 14 个月至 8 岁，中位数为 3 岁。16 名患者为女性（52%），24 名患者接受了睫状肌麻痹验光。其中，20.8%存在显著的屈光不正；在存在屈光不正的患者中，40%为近视，60%为远视。8 名患者（25.8%）存在视乳头水肿，颅颌面手术后明显改善。5 名患者（16%）在基线时至少有一只眼的视力≤20/30，随访时视力有所改善。
颅缝早闭对阿拉伯人群的视觉功能有显著影响。常见到可矫正的视力损害病例，例如由弱视性屈光不正和视乳头水肿引起的视力损害；因此，建议对这些患者及时转诊并进行定期眼科评估。
