大鼠脑室内注射6-羟基多巴胺后皮肤电导活动的两种变化类型。
Two types of changes in skin conductance activity after intraventricular administration of 6-hydroxydopamine in rats.
作者信息
Yamamoto K, Kiyosumi H, Yamaguchi K, Moroji T
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 1985;9(3):245-50. doi: 10.1016/0278-5846(85)90087-9.
Sixteen male Wistar strain rats were trained to have their skin conductance activity recorded through the soles of their hind limbs, and the effects of the intraventricular administration of 6-OHDA (200 micrograms) on this activity were studied. The intact rats showed skin conductance response and its habituation to repeated auditory stimuli (500 Hz, 90 dB, 1 sec). The 6-OHDA-treated rats exhibited either obliteration of the response or impairment of the habituation. The nonresponding state tended to be accompanied by a low rate of spontaneous skin conductance fluctuation, but the nonhabituating state was not accompanied by changes of the rate. The vehicle-treated rats showed no change in these activities. These electrodermal characteristics were discussed along with the CA hypothesis of schizophrenia.
选用16只雄性Wistar品系大鼠，训练通过其后肢足底记录其皮肤电导活动，并研究脑室内注射6-羟基多巴胺（200微克）对该活动的影响。完整大鼠表现出皮肤电导反应及其对重复听觉刺激（500赫兹、90分贝、1秒）的习惯化。经6-羟基多巴胺处理的大鼠表现出反应消失或习惯化受损。无反应状态往往伴随着自发皮肤电导波动率较低，但非习惯化状态则未伴随着该率的变化。注射赋形剂的大鼠在这些活动中未显示出变化。结合精神分裂症的CA假说对这些皮电特征进行了讨论。
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