脑室内注射6-羟基多巴胺可增加大鼠脑内各区域促甲状腺激素释放激素（TRH）的含量。

Intraventricular 6-hydroxydopamine increases thyrotropin-releasing hormone (TRH) content in regions of rat brain.

作者信息

Engber T M, Manaker S, Kreider M S, Winokur A

出版信息

Regul Pept. 1985 Sep;12(1):51-7. doi: 10.1016/0167-0115(85)90186-7.

Abstract

Rats were given intraventricular (ivt) injections of various doses (50-400 micrograms, hydrobromide salt) of 6-hydroxydopamine (6-OHDA) and killed 1, 3 or 6 days later. Brains were removed, dissected into 11 regions, and the thyrotropin-releasing hormone (TRH) content of each region was measured by radioimmunoassay. 6-OHDA (400 micrograms) caused significant elevations in the TRH content of 6 regions: olfactory bulb, anterior cortex, brainstem, posterior cortex, hippocampus, and amygdala-piriform cortex. The magnitude of these increases ranged from 59% in olfactory bulb to 497% in hippocampus and was, in all cases, greatest at 3 days. These results suggest that the TRH content of certain brain regions may be regulated by catecholamine neurotransmitters.

摘要

给大鼠脑室内注射不同剂量（50 - 400微克，氢溴酸盐）的6 - 羟基多巴胺（6 - OHDA），并在1、3或6天后处死。取出大脑，切成11个区域，通过放射免疫分析法测定每个区域促甲状腺激素释放激素（TRH）的含量。6 - OHDA（400微克）导致6个区域的TRH含量显著升高：嗅球、前额叶皮质、脑干、后皮质、海马体和杏仁核 - 梨状皮质。这些增加的幅度从嗅球的59%到海马体的497%不等，并且在所有情况下，3天时增加幅度最大。这些结果表明，某些脑区的TRH含量可能受儿茶酚胺神经递质调节。