破解糖尿病性骨悖论：AGEs 如何破坏骨骼完整性。
Decoding the diabetic bone paradox: How AGEs sabotage skeletal integrity.
机构信息
Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, P.R. China.
Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, P.R. China.
出版信息
Cell Rep Med. 2024 Sep 17;5(9):101693. doi: 10.1016/j.xcrm.2024.101693.
Diabetes patients often suffer from fractures despite normal or high bone mineral density, a phenomenon known as the diabetic bone paradox. Gao et al. identify AGEs as disrupting bone quality and compromising skeletal integrity in diabetic bone disease.
糖尿病患者尽管骨密度正常或较高，仍经常发生骨折，这种现象被称为糖尿病骨悖论。高等人发现，AGEs 会破坏骨质量，损害糖尿病性骨病中的骨骼完整性。
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