Martin-Body R L, Sinclair J D
Respir Physiol. 1985 Jul;61(1):105-13. doi: 10.1016/0034-5687(85)90032-5.
Respiratory patterns have been studied in awake and halothane anaesthetised rats. Tidal volume (VT) was shown to be age-sensitive over 44-200 days; failure to account for this gave the appearance of an increased ventilatory sensitivity to CO2 with age. Inspiration of CO2 (0-10.5%) produced linear responses of VT whereas frequency responses stabilised at 6% CO2. Initially expiratory duration (TE) decreased more than inspiratory duration (TI) and both decreased linearly relative to increased VT; above 6% CO2, increases in VT occurred with only minor changes in TI and TE. Halothane anaesthesia dominantly depressed the frequency response to CO2. We conclude that the rat shows a great influence of vagal control on breathing in the awake state and in halothane anaesthesia; that TE is controlled independently of TI; and that respiratory frequency is more rigorously controlled than VT.
对清醒和氟烷麻醉的大鼠的呼吸模式进行了研究。潮气量（VT）在44 - 200天内显示出对年龄敏感；未考虑这一点会导致出现随着年龄增长对二氧化碳通气敏感性增加的假象。吸入二氧化碳（0 - 10.5%）会使VT产生线性反应，而频率反应在6%二氧化碳时稳定下来。最初，呼气持续时间（TE）的减少比吸气持续时间（TI）更多，并且两者相对于VT增加呈线性减少；在6%二氧化碳以上，VT增加时TI和TE仅有微小变化。氟烷麻醉主要抑制对二氧化碳的频率反应。我们得出结论，大鼠在清醒状态和氟烷麻醉下，迷走神经控制对呼吸有很大影响；TE是独立于TI进行控制的；并且呼吸频率比VT受到更严格的控制。
