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白化病基因杂合的正常色素沉着猫的视觉通路异常。

Abnormal visual pathways in normally pigmented cats that are heterozygous for albinism.

作者信息

Leventhal A G, Vitek D J, Creel D J

出版信息

Science. 1985 Sep 27;229(4720):1395-7. doi: 10.1126/science.3929383.

Abstract

The various forms of albinism affect about one in 10,000 births in the United States. An additional 1 to 2 percent of the population has normal pigmentation but is heterozygous and carries a recessive allele for albinism. The retinogeniculocortical pathways were studied in normally pigmented cats that carry a recessive allele for albinism. The cats exhibited abnormalities in their visual pathways similar to those present in homozygous albinos. These results imply that visual anomalies like those found in albinos may be present in 1 to 2 percent of the human population.

摘要

在美国,各种形式的白化病影响着约万分之一的新生儿。另外1%至2%的人口色素沉着正常,但为白化病隐性等位基因的杂合子携带者。对携带白化病隐性等位基因的正常色素沉着猫的视网膜-膝状体-皮质通路进行了研究。这些猫的视觉通路出现了与纯合白化病患者类似的异常。这些结果表明,在1%至2%的人群中可能存在与白化病患者类似的视觉异常。

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