Department of Pediatric Medicine, Taizhou Women and Children's Hospital of Wenzhou Medical University, Taizhou, Zhejiang, China.
Department of Pediatric Medicine, Taizhou Women and Children's Hospital of Wenzhou Medical University, Taizhou, Zhejiang, China
Ann Clin Lab Sci. 2024 Jul;54(4):452-456.
To observe the effect of low-dose azithromycin on pulmonary ventilation function and inflammatory factors IL-6, IL-13 in children with bronchial asthma.
A total of 80 children with asthma in Pediatric Medicine affiliated to Taizhou Women and Children's Hospital of Wenzhou Medical University from January 2019 to December 2022 were selected and divided into control group (42 cases) and study group (38 cases). The control group regularly inhaled Salmeterol Xinafoate and Fluticasone Propionate inhalation, while the study group was additionally given low-dose azithromycin. After four weeks of treatment, pulmonary function tests including FEV1, FVC were performed and inflammatory indicators including CRP, FeNO, IL-6, IL-13 were measured. The occurrence of adverse reactions during treatment was recorded.
Pulmonary function tests including FEV1%, FEV1/FVC% were improved in all subjects, and the improvement of pulmonary function was more significant in the study group (<0.05). The levels of CRP, FeNO, IL-6 and IL-13 were decreased in the two groups, especially in the study group (<0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups (>0.05).
Low-dose azithromycin can significantly improve the pulmonary function in children with bronchial asthma, reduce the levels of inflammatory factors, control airway mucus secretion and inflammation, and can be used to treat chronic lung diseases such as bronchial asthma.
观察小剂量阿奇霉素对支气管哮喘患儿肺通气功能及白细胞介素 6（IL-6）、白细胞介素 13（IL-13）等炎症因子的影响。
选取温州医科大学附属台州妇女儿童医院儿科医学科 2019 年 1 月至 2022 年 12 月收治的支气管哮喘患儿 80 例，按随机数字表法分为对照组（42 例）和观察组（38 例）。对照组患儿规律吸入沙美特罗替卡松、丙酸氟替卡松，观察组患儿在对照组基础上联合小剂量阿奇霉素治疗。治疗 4 周后，检测两组患儿的肺功能[第 1 秒用力呼气容积（FEV1）、用力肺活量（FVC）]，检测两组患儿的炎症指标[C 反应蛋白（CRP）、呼出气一氧化氮（FeNO）、IL-6、IL-13]，记录治疗期间不良反应发生情况。
两组患儿的 FEV1%、FEV1/FVC%等肺功能指标均较治疗前改善，且观察组改善更显著（<0.05）；两组患儿的 CRP、FeNO、IL-6、IL-13 水平均较治疗前降低，且观察组降低更显著（<0.05）；两组患儿不良反应发生率比较，差异无统计学意义（>0.05）。
小剂量阿奇霉素能显著改善支气管哮喘患儿的肺功能，降低炎症因子水平，控制气道黏液分泌和炎症反应，可用于支气管哮喘等慢性肺部疾病的治疗。
