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[肺通气功能正常的支气管哮喘儿童急性发作的控制状况及随访]

[Control status and follow-up of acute attacks in children with bronchial asthma with normal pulmonary ventilation function].

作者信息

Ma Lan-Lan, Chen Ling, Wang Qin, Xu Yang-Guang, Chen Xing

机构信息

Department of Pediatric Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2024 May 15;26(5):476-480. doi: 10.7499/j.issn.1008-8830.2311149.

Abstract

OBJECTIVES

To investigate the control status of bronchial asthma (referred to as "asthma") in school-age children with normal pulmonary ventilation function and the occurrence of acute attacks within 1 year of follow-up.

METHODS

A retrospective analysis was conducted on clinical data of 327 children aged 6-14 years with bronchial asthma and normal pulmonary ventilation function from April to September 2021. Based on the measured value of one second rate (FEV/FVC), the children were divided into the ≥80% group (267 cases) and the <80% group (60 cases). The pulmonary ventilation function, asthma control level, and occurrence of acute attacks within 1 year were compared between the two groups.

RESULTS

The baseline pulmonary ventilation function in the <80% group was lower than that in the ≥80% group, and the proportion of small airway dysfunction was higher than that in the ≥80% group (<0.05). After standardized treatment for 1 year, the small airway function indices in the <80% group improved but remained lower than those in the ≥80% group (<0.05). The rate of incomplete asthma control at baseline was 34.6% (113/327), and the asthma control level in the <80% group was lower than that in the ≥80% group (<0.05). After standardized treatment for 1 year, the asthma control level in the <80% group remained lower than that in the ≥80% group, and the proportion of acute asthma attacks was higher than that in the ≥80% group (<0.05).

CONCLUSIONS

Approximately one-third of school-age children with asthma still have incomplete asthma control when their pulmonary ventilation function is normal. Among them, children with measured FEV/FVC<80% have an increased risk of acute asthma attacks and require close follow-up and strengthened asthma management.

摘要

目的

探讨肺通气功能正常的学龄期儿童支气管哮喘(简称“哮喘”)的控制状况及随访1年内急性发作情况。

方法

对2021年4月至9月327例6~14岁肺通气功能正常的支气管哮喘患儿临床资料进行回顾性分析。根据一秒率(FEV/FVC)测定值,将患儿分为≥80%组(267例)和<80%组(60例)。比较两组肺通气功能、哮喘控制水平及随访1年内急性发作情况。

结果

<80%组基线肺通气功能低于≥80%组,小气道功能障碍比例高于≥80%组(P<0.05)。标准化治疗1年后,<80%组小气道功能指标有所改善,但仍低于≥80%组(P<0.05)。基线时哮喘控制不佳率为34.6%(113/327),<80%组哮喘控制水平低于≥80%组(P<0.05)。标准化治疗1年后,<80%组哮喘控制水平仍低于≥80%组,急性哮喘发作比例高于≥80%组(P<0.05)。

结论

约三分之一肺通气功能正常的学龄期哮喘患儿哮喘控制不佳。其中,FEV/FVC测定值<80%的患儿急性哮喘发作风险增加,需密切随访并加强哮喘管理。

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