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伴放线聚集杆菌相关性蝶窦炎导致眶蜂窝织炎、脑膜炎和静脉窦血栓形成

Aggregatibacter aphrophilus-associated Sphenoid Sinusitis Causing Orbital Cellulitis, Meningitis, and Venous Sinus Thrombosis.

作者信息

Ohashi Nobuhiko, Kawamura Yoshino, Kamijima Shota, Watanabe Rie, Yamazaki Shintaro, Matsushima Nodoka, Tazawa Ko-Ichi

机构信息

Department of Neurology, Nagano Red Cross Hospital, Japan.

Department of Otorhinolaryngology, Nagano Red Cross Hospital, Japan.

出版信息

Intern Med. 2025 May 1;64(9):1434-1439. doi: 10.2169/internalmedicine.3965-24. Epub 2024 Sep 18.

DOI:10.2169/internalmedicine.3965-24
PMID:39293984
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12120218/
Abstract

We herein report an 81-year-old woman with no significant medical history who developed a fever, headache, and right eyelid swelling. Magnetic resonance imaging (MRI) showed eye proptosis, sphenoid opacity, enlarged cavernous sinus, and dilated right superior ophthalmic vein (SOV). Subsequent enhanced MRI revealed intraventricular debris and thrombosis in the right SOV and the left transverse and sigmoid sinuses. Blood cultures were positive for Aggregatibacter aphrophilus, as identified by mass spectrometry. The patient responded well to antibiotics, anticoagulants, and surgical drainage of sphenoid sinusitis. To our knowledge, this is the first case of A. aphrophilus sphenoid sinusitis causing orbital cellulitis, meningitis, and venous sinus thrombosis.

摘要

我们在此报告一名81岁女性，既往无重大病史，出现发热、头痛及右侧眼睑肿胀。磁共振成像（MRI）显示眼球突出、蝶窦混浊、海绵窦增大及右侧眼上静脉（SOV）扩张。随后的增强MRI显示脑室内有碎屑，右侧SOV以及左侧横窦和乙状窦有血栓形成。通过质谱鉴定，血培养结果显示嗜沫聚集杆菌呈阳性。患者对抗生素、抗凝剂及蝶窦炎手术引流反应良好。据我们所知，这是首例由嗜沫聚集杆菌引起的蝶窦炎导致眶蜂窝织炎、脑膜炎及静脉窦血栓形成的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bc/12120218/4f407c5dce4a/1349-7235-64-1434-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bc/12120218/f8566d13f60d/1349-7235-64-1434-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bc/12120218/6e17fa77ab99/1349-7235-64-1434-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bc/12120218/89e42b62b232/1349-7235-64-1434-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bc/12120218/4f407c5dce4a/1349-7235-64-1434-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bc/12120218/f8566d13f60d/1349-7235-64-1434-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bc/12120218/6e17fa77ab99/1349-7235-64-1434-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bc/12120218/89e42b62b232/1349-7235-64-1434-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bc/12120218/4f407c5dce4a/1349-7235-64-1434-g004.jpg

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