Jang Subin, Ryder Justin R, Kelly Aaron S, Bomberg Eric M
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Center for Pediatric Obesity Medicine, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
Pediatr Res. 2024 Sep 18. doi: 10.1038/s41390-024-03578-6.
While endogenous sex hormones (e.g., testosterone, estradiol) are important factors regulating adipose tissue distribution, studies evaluating such relationships in youth across a wide weight status spectrum are limited.
We performed a cross-sectional analysis of 8-21-year-old youth. Multiple linear regression models were used to evaluate associations between sex hormones and adiposity measures (android/gynoid ratio (A/G), total fat mass (FM), visceral adipose tissue (VAT), waist circumference (WC)) and total lean mass (LM), adjusting for pubertal stage and race/ethnicity, and stratified by sex and weight status.
Among 342 youth, the mean age was 13.0 ± 2.8 years old (52.6% female; 38.9% normal weight [NW]; 27.8% overweight/obesity [OW/OB]; 33.3% severe obesity [SO]). Testosterone was positively associated with LM among males with NW (1462 g, 95% CI: 255-2668 g) and OW/OB (3792 g, 95% CI: 1244-6340 g), with A/G and WC among males with NW (0.01, 95% CI: 0-0.2 and 10 mm, 95% CI: 4-16 mm, respectively), and negatively associated with WC among males with SO (-43 mm, -81 to -5 mm). Estradiol was positively associated with A/G, FM, and WC among males with SO, and VAT in females with NW.
Our findings showed that sex hormones were associated with adipose tissue deposition in youth across the weight spectrum.
Sex hormones (e.g., testosterone, estradiol) are associated with various adiposity measures among male and female children and adolescents across a weight status spectrum. We evaluated associations between sex hormones and various adiposity measures among 8-21-year-olds across a weight status spectrum (normal weight, overweight/class 1 obesity, class 2-3 obesity). We found that estradiol was positively associated with total fat mass, android/gynoid ratio, and waist circumference in males with class 2-3 obesity, and testosterone was positively associated with lean mass in males with normal weight and overweight/class 1 obesity. Sex hormones may influence, or may be influenced by, adiposity in youth.
虽然内源性性激素（如睾酮、雌二醇）是调节脂肪组织分布的重要因素，但评估不同体重状况的青少年中此类关系的研究有限。
我们对8至21岁的青少年进行了横断面分析。使用多元线性回归模型评估性激素与肥胖指标（男性/女性脂肪比例（A/G）、总脂肪量（FM）、内脏脂肪组织（VAT）、腰围（WC））和总瘦体重（LM）之间的关联，并对青春期阶段和种族/民族进行了调整，同时按性别和体重状况进行分层。
在342名青少年中，平均年龄为13.0±2.8岁（52.6%为女性；38.9%为正常体重[NW]；27.8%为超重/肥胖[OW/OB]；33.3%为重度肥胖[SO]）。睾酮与NW男性（1462g，95%CI：255-2668g）和OW/OB男性（3792g，95%CI：1244-6340g）的LM呈正相关，与NW男性的A/G和WC呈正相关（分别为0.01，95%CI：0-0.2和10mm，95%CI：4-16mm），与SO男性的WC呈负相关（-43mm，-81至-5mm）。雌二醇与SO男性的A/G、FM和WC呈正相关，与NW女性的VAT呈正相关。
我们的研究结果表明，性激素与不同体重范围的青少年脂肪组织沉积有关。
性激素（如睾酮、雌二醇）与不同体重状况的男性和女性儿童及青少年的各种肥胖指标有关。我们评估了8至21岁不同体重状况（正常体重、超重/1级肥胖、2-3级肥胖）的青少年中性激素与各种肥胖指标之间的关联。我们发现，雌二醇与2-3级肥胖男性的总脂肪量、男性/女性脂肪比例和腰围呈正相关，睾酮与正常体重和超重/1级肥胖男性的瘦体重呈正相关。性激素可能影响青少年的肥胖，或者可能受青少年肥胖的影响。
