Laboratory of Functional Physiology, Department of Environmental and Life Sciences, School of Food and Nutritional Sciences, University of Shizuoka, Yada 52-1, Suruga-Ku, Shizuoka, Shizuoka, 422-8526, Japan.
Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.
J Physiol Sci. 2024 Sep 18;74(1):43. doi: 10.1186/s12576-024-00937-0.
Temperature detection is essential for the survival and perpetuation of any species. Thermoreceptors in the skin sense body temperature as well as the temperatures of ambient air and objects. Since Dr. David Julius and his colleagues discovered that TRPV1 is expressed in small-diameter primary sensory neurons, and activated by temperatures above 42 °C, 11 of thermo-sensitive TRP channels have been identified. TRPM3 expressed in sensory neurons acts as a sensor for noxious heat. TRPM4 and TRPM5 are Ca⁺-activated monovalent cation channels, and their activity is drastically potentiated by temperature increase. This review aims to summarize the expression patterns, electrophysiological properties, and physiological roles of TRPM3, TRPM4, and TRPM5 associated with thermosensation.
温度检测对于任何物种的生存和延续都是至关重要的。皮肤中的热敏感受器既能感知体温，也能感知环境空气和物体的温度。自从 David Julius 博士和他的同事发现 TRPV1 表达于小直径初级感觉神经元，并被 42°C 以上的温度激活以来，已经鉴定出 11 种热敏性 TRP 通道。表达于感觉神经元中的 TRPM3 充当有害热的传感器。TRPM4 和 TRPM5 是 Ca²⁺激活的单价阳离子通道，其活性被温度升高大大增强。本综述旨在总结与热敏性相关的 TRPM3、TRPM4 和 TRPM5 的表达模式、电生理特性和生理作用。
