Department of Endocrinology, Dalian Municipal Central Hospital, Dalian, China.
Dalian municipal Central Hospital, China Medical University, Shenyang, China.
BMC Endocr Disord. 2024 Sep 18;24(1):191. doi: 10.1186/s12902-024-01718-x.
In recent times, a number of new indices for measuring visceral obesity have been developed. This research sought to investigate the relationship between four visceral obesity indices and prediabetes and diabetes.
Conducted in 2011 as a cross-sectional analysis in Dalian, China, this study utilized logistic regression models to explore the relationships between four visceral obesity indices and prediabetes and diabetes. It also assessed the dose-response relationships using restricted cubic splines (RCS), performed subgroup analyses, and conducted interaction tests. The predictive values of four visceral obesity indices were evaluated using receiver operating characteristic (ROC) curves.
The study enrolled 10,090 participants, with prediabetes and diabetes prevalence at 80.53%. Multifactorial logistic regression revealed positive relationships between the four visceral obesity indices and prediabetes and diabetes. The results of the RCS analysis revealed a linear relationship between the body roundness index (BRI), cardiometabolic index (CMI) and prediabetes and diabetes. Conversely, a non-linear relationship was observed between Chinese visceral adiposity index (CVAI), lipid accumulation product (LAP) and prediabetes and diabetes. Subgroup analyses demonstrated stronger relationships of CMI, CVAI, and LAP with prediabetes and diabetes among females. ROC curves suggested that LAP could be an effective predictor of these conditions.
This research confirmed that four visceral obesity indices are linked with a higher risk of prediabetes and diabetes in middle-aged and elderly individuals in Dalian. Importantly, LAP could be an effective predictor of prediabetes and diabetes. Effective weight management significantly reduces the risk of both prediabetes and diabetes.
近年来，已经开发出许多新的衡量内脏肥胖的指数。本研究旨在探讨四种内脏肥胖指数与糖尿病前期和糖尿病之间的关系。
该研究于 2011 年在中国大连进行，是一项横断面分析。研究采用逻辑回归模型探讨了四种内脏肥胖指数与糖尿病前期和糖尿病之间的关系。还使用限制性立方样条（RCS）评估了剂量反应关系，进行了亚组分析，并进行了交互检验。使用接收者操作特征（ROC）曲线评估了四种内脏肥胖指数的预测价值。
该研究纳入了 10090 名参与者，糖尿病前期和糖尿病的患病率为 80.53%。多因素逻辑回归显示，四种内脏肥胖指数与糖尿病前期和糖尿病呈正相关。RCS 分析的结果显示，体圆度指数（BRI）和心血管代谢指数（CMI）与糖尿病前期和糖尿病之间存在线性关系。相反，中国内脏脂肪指数（CVAI）和脂质蓄积产物（LAP）与糖尿病前期和糖尿病之间存在非线性关系。亚组分析表明，CMI、CVAI 和 LAP 与女性糖尿病前期和糖尿病的关系更强。ROC 曲线表明，LAP 可能是这些疾病的有效预测指标。
本研究证实，四种内脏肥胖指数与大连中老年人群糖尿病前期和糖尿病的风险增加有关。重要的是，LAP 可能是糖尿病前期和糖尿病的有效预测指标。有效的体重管理可以显著降低糖尿病前期和糖尿病的风险。
