Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, 179, Gudeok-Ro, Seo-Gu, Busan, Republic of Korea.
Department of Nuclear Medicine, College of Medicine, Pusan National University, Yangsan, 50612, Republic of Korea.
Sci Rep. 2023 Oct 20;13(1):17902. doi: 10.1038/s41598-023-45100-8.
Visceral adipose tissue (VAT) is a well-established risk factor for the development of diabetes in individuals with prediabetes. We aimed to evaluate various adiposity and metabolic indices, including visceral adipose tissue (VAT) volume measured by CT, in individuals with prediabetes, based on their different subtypes. This retrospective study included 78 prediabetes individuals aged ≥ 20 years whose VAT volumes were evaluated by CT. Individuals were classified into prediabetes subtypes: impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and combined IFG and IGT (C-IFG/IGT). We conducted a comparison of the patients' adiposity indices and their associations with one other, as well as with insulin resistance, based on the different prediabetes subtypes. Individuals with C-IFG/IGT had higher levels of visceral obesity than those with IFG or IGT. VAT volume was more strongly associated with insulin resistance than other adiposity indices, regardless of prediabetes subtypes. Additionally, VAT volume and liver attenuation index showed a significant correlation with the other indices studied across the prediabetes subtypes. CT-based measurement of VAT volume may be a valuable tool for evaluating metabolic risk factors among individuals with prediabetes.
内脏脂肪组织（VAT）是糖尿病前期个体发生糖尿病的一个既定危险因素。我们旨在根据不同的亚型评估糖尿病前期个体的各种肥胖和代谢指标，包括 CT 测量的内脏脂肪组织（VAT）体积。这项回顾性研究纳入了 78 名年龄≥20 岁的糖尿病前期个体，他们的 VAT 体积通过 CT 进行评估。个体被分为糖尿病前期亚型：空腹血糖受损（IFG）、葡萄糖耐量受损（IGT）和 IFG 和 IGT 合并（C-IFG/IGT）。我们根据不同的糖尿病前期亚型比较了患者的肥胖指数及其与其他指数的相关性，以及与胰岛素抵抗的相关性。C-IFG/IGT 个体的内脏肥胖水平高于 IFG 或 IGT 个体。VAT 体积与胰岛素抵抗的相关性强于其他肥胖指数，无论糖尿病前期亚型如何。此外，VAT 体积和肝脏衰减指数与糖尿病前期各亚型研究的其他指数之间存在显著相关性。基于 CT 的 VAT 体积测量可能是评估糖尿病前期个体代谢危险因素的有用工具。
