Makerere University School of Public Health, Kampala, Uganda.
Baylor College of Medicine Children's Foundation, Mulago Hospital Complex, Kampala, Uganda.
BMC Health Serv Res. 2024 Sep 19;24(1):1093. doi: 10.1186/s12913-024-11528-5.
BACKGROUND: Among people living with HIV(PHIV) with unsuppressed viral load after six or more months of anti-retroviral therapy (ART), three intensive adherence counseling sessions (IAC) sessions are recommended. However, there is limited information about IAC completion rates. We investigated the factors associated with IAC completion among PLHIV with an unsuppressed viral load on first and second-line ART in mid-western Uganda. METHODS: In this retrospective review of medical records, we abstracted routine HIV data between January 2018 and September 2019 at the Fort Portal Regional Hospital. IAC completion was the primary outcome measured as the receipt of ≥ 3 consecutive good ART adherence scores of ≥ 95.0% during the IAC sessions, spaced one month apart within three months. The modified Poisson regression analysis with robust standard errors was used to determine factors associated with the outcome, reported as risk ratio (RR) and 95% confidence interval (CI). RESULTS: We studied 420 participants of whom 204 (48.6%) were aged 20-39 years (mean age, 33.6 ± 13.3 years) and 243 (57.9%) were female. 282 (67.1%) participants completed their IAC sessions. Secondary or higher levels of education (Adjusted RR (aRR) 0.79, 95% CI 0.64-0.98), no follow-up for IAC (aRR 0.76, 95% CI 0.67-0.87), malnutrition (aRR 0.65, 95% CI 0.43-0.99) were associated with a lower likelihood of IAC completion while being in a separated/widowed or divorced relationship (aRR 1.23, 95% CI 1.01-1.49) was associated with a higher likelihood of IAC completion. CONCLUSIONS: We found a low IAC completion rate compared to the desired target of 100%. Nutritional support for malnourished PLHIV receiving IAC, follow-ups, and targeted health education on the importance of IAC are needed to improve the IAC completion rate.
背景:在接受抗逆转录病毒疗法(ART)治疗六个月或更长时间后病毒载量仍未得到抑制的艾滋病毒感染者(PLHIV)中,建议进行三次强化依从性咨询(IAC)。然而,关于 IAC 完成率的信息有限。我们在乌干达中西部地区调查了接受一线和二线 ART 治疗但病毒载量仍未得到抑制的 PLHIV 中与 IAC 完成相关的因素。
方法:在这项对病历的回顾性研究中,我们于 2018 年 1 月至 2019 年 9 月在福托波尔地区医院提取了常规 HIV 数据。IAC 完成情况是主要结果,定义为在三个月内,相隔一个月,三次 IAC 期间连续三次获得≥95.0%的良好 ART 依从性评分。采用稳健标准误差的修正泊松回归分析来确定与结果相关的因素,以风险比(RR)和 95%置信区间(CI)报告。
结果:我们研究了 420 名参与者,其中 204 名(48.6%)年龄在 20-39 岁(平均年龄 33.6±13.3 岁),243 名(57.9%)为女性。282 名(67.1%)参与者完成了 IAC 课程。中等或高等教育程度(调整后的 RR(aRR)0.79,95%CI 0.64-0.98)、IAC 无随访(aRR 0.76,95%CI 0.67-0.87)、营养不良(aRR 0.65,95%CI 0.43-0.99)与 IAC 完成的可能性降低相关,而处于分居/丧偶或离婚关系(aRR 1.23,95%CI 1.01-1.49)与 IAC 完成的可能性增加相关。
结论:与 100%的目标相比,我们发现 IAC 完成率较低。需要为接受 IAC 的营养不良 PLHIV 提供营养支持、随访,并进行关于 IAC 重要性的针对性健康教育,以提高 IAC 完成率。
BMC Public Health. 2021-3-6