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乌干达一家大型转诊医院中,与艾滋病毒感染者完成强化依从性咨询相关的因素:回顾性分析。

Factors associated with completion of intensive adherence counseling among people living with HIV at a large referral hospital in Uganda: a retrospective analysis.

机构信息

Makerere University School of Public Health, Kampala, Uganda.

Baylor College of Medicine Children's Foundation, Mulago Hospital Complex, Kampala, Uganda.

出版信息

BMC Health Serv Res. 2024 Sep 19;24(1):1093. doi: 10.1186/s12913-024-11528-5.


DOI:10.1186/s12913-024-11528-5
PMID:39294641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11411857/
Abstract

BACKGROUND: Among people living with HIV(PHIV) with unsuppressed viral load after six or more months of anti-retroviral therapy (ART), three intensive adherence counseling sessions (IAC) sessions are recommended. However, there is limited information about IAC completion rates. We investigated the factors associated with IAC completion among PLHIV with an unsuppressed viral load on first and second-line ART in mid-western Uganda. METHODS: In this retrospective review of medical records, we abstracted routine HIV data between January 2018 and September 2019 at the Fort Portal Regional Hospital. IAC completion was the primary outcome measured as the receipt of ≥ 3 consecutive good ART adherence scores of ≥ 95.0% during the IAC sessions, spaced one month apart within three months. The modified Poisson regression analysis with robust standard errors was used to determine factors associated with the outcome, reported as risk ratio (RR) and 95% confidence interval (CI). RESULTS: We studied 420 participants of whom 204 (48.6%) were aged 20-39 years (mean age, 33.6 ± 13.3 years) and 243 (57.9%) were female. 282 (67.1%) participants completed their IAC sessions. Secondary or higher levels of education (Adjusted RR (aRR) 0.79, 95% CI 0.64-0.98), no follow-up for IAC (aRR 0.76, 95% CI 0.67-0.87), malnutrition (aRR 0.65, 95% CI 0.43-0.99) were associated with a lower likelihood of IAC completion while being in a separated/widowed or divorced relationship (aRR 1.23, 95% CI 1.01-1.49) was associated with a higher likelihood of IAC completion. CONCLUSIONS: We found a low IAC completion rate compared to the desired target of 100%. Nutritional support for malnourished PLHIV receiving IAC, follow-ups, and targeted health education on the importance of IAC are needed to improve the IAC completion rate.

摘要

背景:在接受抗逆转录病毒疗法(ART)治疗六个月或更长时间后病毒载量仍未得到抑制的艾滋病毒感染者(PLHIV)中,建议进行三次强化依从性咨询(IAC)。然而,关于 IAC 完成率的信息有限。我们在乌干达中西部地区调查了接受一线和二线 ART 治疗但病毒载量仍未得到抑制的 PLHIV 中与 IAC 完成相关的因素。

方法:在这项对病历的回顾性研究中,我们于 2018 年 1 月至 2019 年 9 月在福托波尔地区医院提取了常规 HIV 数据。IAC 完成情况是主要结果,定义为在三个月内,相隔一个月,三次 IAC 期间连续三次获得≥95.0%的良好 ART 依从性评分。采用稳健标准误差的修正泊松回归分析来确定与结果相关的因素,以风险比(RR)和 95%置信区间(CI)报告。

结果:我们研究了 420 名参与者,其中 204 名(48.6%)年龄在 20-39 岁(平均年龄 33.6±13.3 岁),243 名(57.9%)为女性。282 名(67.1%)参与者完成了 IAC 课程。中等或高等教育程度(调整后的 RR(aRR)0.79,95%CI 0.64-0.98)、IAC 无随访(aRR 0.76,95%CI 0.67-0.87)、营养不良(aRR 0.65,95%CI 0.43-0.99)与 IAC 完成的可能性降低相关,而处于分居/丧偶或离婚关系(aRR 1.23,95%CI 1.01-1.49)与 IAC 完成的可能性增加相关。

结论:与 100%的目标相比,我们发现 IAC 完成率较低。需要为接受 IAC 的营养不良 PLHIV 提供营养支持、随访,并进行关于 IAC 重要性的针对性健康教育,以提高 IAC 完成率。

相似文献

[1]
Factors associated with completion of intensive adherence counseling among people living with HIV at a large referral hospital in Uganda: a retrospective analysis.

BMC Health Serv Res. 2024-9-19

[2]
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AIDS Res Ther. 2023-3-30

[3]
Unsuppressed viral load after intensive adherence counselling in rural eastern Uganda; a case of Kamuli district, Uganda.

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[4]
Effect and implementation experience of intensive adherence counseling in a public HIV care center in Uganda: a mixed-methods study.

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[5]
Low HIV viral suppression rates following the intensive adherence counseling (IAC) program for children and adolescents with viral failure in public health facilities in Uganda.

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[6]
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AIDS Res Ther. 2023-12-19

[7]
Barriers and facilitators to viral load suppression among people living with HIV following intensive adherence counseling in Kampala, Uganda: A qualitative study.

Soc Sci Med. 2024-2

[8]
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[9]
Effectiveness of intensive adherence counselling in achieving an undetectable viral load among people on antiretroviral therapy with low-level viraemia in Uganda.

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[10]
HIV viral load suppression following intensive adherence counseling among people living with HIV on treatment at military-managed health facilities in Uganda.

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引用本文的文献

[1]
Effect of Active Follow-Up on Viral Load Suppression among People Living with HIV on Intensive Adherence Counseling in Uganda: An Instrumental Variable Analysis.

Am J Trop Med Hyg. 2025-2-25

本文引用的文献

[1]
Factors associated with an unsuppressed viral load among HIV-positive individuals attending STI services in South Africa, 2019.

BMC Infect Dis. 2024-1-30

[2]
Antiretroviral treatment failure and associated factors among people living with HIV on therapy in Homa Bay, Kenya: A retrospective study.

PLOS Glob Public Health. 2023-3-2

[3]
Unsuppressed viral load after intensive adherence counselling in rural eastern Uganda; a case of Kamuli district, Uganda.

BMC Public Health. 2021-12-18

[4]
Effect and implementation experience of intensive adherence counseling in a public HIV care center in Uganda: a mixed-methods study.

BMC Infect Dis. 2021-11-19

[5]
HIV viral load suppression following intensive adherence counseling among people living with HIV on treatment at military-managed health facilities in Uganda.

Int J Infect Dis. 2021-11

[6]
The impact of food insecurity on HIV outcomes in Senegal, West Africa: a prospective longitudinal study.

BMC Public Health. 2021-3-6

[7]
Viral Load Suppression after Enhanced Adherence Counseling and Its Predictors among High Viral Load HIV Seropositive People in North Wollo Zone Public Hospitals, Northeast Ethiopia, 2019: Retrospective Cohort Study.

AIDS Res Treat. 2020-4-21

[8]
HIV viral resuppression following an elevated viral load: a systematic review and meta-analysis.

J Int AIDS Soc. 2019-11

[9]
Lack of effectiveness of adherence counselling in reversing virological failure among patients on long-term antiretroviral therapy in rural Uganda.

HIV Med. 2020-1

[10]
A Review of Differentiated Service Delivery for HIV Treatment: Effectiveness, Mechanisms, Targeting, and Scale.

Curr HIV/AIDS Rep. 2019-8

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