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糖尿病对中国东部地区结核病复发的影响：一项回顾性队列研究。

The impact of diabetes mellitus on tuberculosis recurrence in Eastern China: a retrospective cohort study.

机构信息

Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, 101 Longmian Ave., Nanjing, 211166, China.

Department of Clinical Laboratory, The Fourth People's Hospital of Lianyungang, Lianyungang, 222000, China.

出版信息

BMC Public Health. 2024 Sep 18;24(1):2534. doi: 10.1186/s12889-024-20019-5.

DOI:10.1186/s12889-024-20019-5
PMID:39294658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11409766/
Abstract

BACKGROUND

The comorbidity of tuberculosis (TB) and diabetes mellitus (DM) is a significant global public health issue. This study aims to explore the recurrence risk and related factors of active pulmonary TB, specifically focusing on the impact of DM.

METHODS

A retrospective cohort study was conducted in Lianyungang City, Jiangsu Province, Eastern China by recruiting 12,509 individuals with newly diagnosed pulmonary TB between 2011 and 2019. The Cox proportional hazards models were performed to identify risk factors of recurrence and assess the association between DM and recurrence. The hazard ratio (HR) and 95% confidence interval (CI) were used to estimate the strength of the association.

RESULTS

After a median follow-up period of 5.46 years, we observed 439 recurrent cases (incident recurrence rate: 6.62 per 1000 person-years). Males (HR: 1.30, 95% CI: 1.03-1.64), patients aged ≥ 60 years (HR: 1.39, 95% CI: 1.15-1.70), DM (HR: 2.40, 95% CI: 1.68-3.45), and etiologic positivity in the initial episode (HR: 2.42, 95% CI: 2.00-2.92) had a significantly increased risk of recurrence.

CONCLUSIONS

Recurrence of pulmonary TB patients who have completed treatment, especially those who also suffer from DM, should be a concern. Enhanced follow-up and targeted surveillance of these high-risk groups are needed.

摘要

背景

结核病（TB）和糖尿病（DM）合并存在是一个重大的全球公共卫生问题。本研究旨在探讨活动性肺结核复发的风险和相关因素，特别是关注 DM 的影响。

方法

采用回顾性队列研究，于 2011 年至 2019 年在江苏省连云港市招募了 12509 例新诊断为肺结核的患者。采用 Cox 比例风险模型确定复发的风险因素，并评估 DM 与复发的关系。采用危险比（HR）和 95%置信区间（CI）来估计关联的强度。

结果

在中位随访 5.46 年后，我们观察到 439 例复发病例（复发发生率：6.62/1000 人年）。男性（HR：1.30，95%CI：1.03-1.64）、年龄≥60 岁的患者（HR：1.39，95%CI：1.15-1.70）、DM（HR：2.40，95%CI：1.68-3.45）和初始发作时病因阳性（HR：2.42，95%CI：2.00-2.92）的患者复发风险显著增加。

结论

完成治疗的肺结核患者，尤其是合并 DM 的患者，应关注其复发情况。需要对这些高危人群进行强化随访和有针对性的监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e6/11409766/1c8407af242b/12889_2024_20019_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e6/11409766/903935f4c891/12889_2024_20019_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e6/11409766/864c05012333/12889_2024_20019_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e6/11409766/6fb4607f80d0/12889_2024_20019_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e6/11409766/1c8407af242b/12889_2024_20019_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e6/11409766/903935f4c891/12889_2024_20019_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e6/11409766/864c05012333/12889_2024_20019_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e6/11409766/6fb4607f80d0/12889_2024_20019_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83e6/11409766/1c8407af242b/12889_2024_20019_Fig4_HTML.jpg

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2
Tuberculosis treatment outcomes of diabetic and non-diabetic TB/HIV co-infected patients: A nationwide observational study in Brazil.糖尿病与非糖尿病结核病/艾滋病合并感染患者的结核病治疗结局：巴西一项全国性观察性研究
Front Med (Lausanne). 2022 Sep 16;9:972145. doi: 10.3389/fmed.2022.972145. eCollection 2022.
3
Investigation on the cause of recurrent tuberculosis in a rural area in China using whole-genome sequencing: A retrospective cohort study.
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Tuberculosis (Edinb). 2022 Mar;133:102174. doi: 10.1016/j.tube.2022.102174. Epub 2022 Jan 31.
4
IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045.国际糖尿病联盟（IDF）糖尿病地图集：2021 年全球、区域和国家糖尿病患病率估算值以及 2045 年预测值。
Diabetes Res Clin Pract. 2022 Jan;183:109119. doi: 10.1016/j.diabres.2021.109119. Epub 2021 Dec 6.
5
Recurrent pulmonary tuberculosis after treatment success: a population-based retrospective study in China.治疗成功后复发性肺结核：一项基于中国人群的回顾性研究。
Clin Microbiol Infect. 2022 May;28(5):684-689. doi: 10.1016/j.cmi.2021.09.022. Epub 2021 Sep 30.
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