Department of Psychology, Northeastern University, Boston, Massachusetts, USA.
Center for Cognitive & Brain Health, Northeastern University, Boston, Massachusetts, USA.
Brain Behav. 2024 Sep;14(9):e70022. doi: 10.1002/brb3.70022.
Prolonged changes to functional network connectivity as a result of a traumatic brain injury (TBI) may relate to long-term cognitive complaints reported by TBI survivors. No interventions have proven to be effective at treating long-term cognitive complaints after TBI but physical activity has been shown to promote cognitive function and modulate functional network connectivity in non-injured adults. Therefore, the objective of this study was to test if physical activity engagement was associated with functional connectivity of the cognitively relevant frontoparietal control network (FPCN) in adults with a TBI history.
In a case-control study design, resting state function magnetic resonance imaging and physical activity data from a subset of participants (18-81 years old) from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study was analyzed. Fifty-seven participants reported a prior head injury with loss of consciousness and 57 age and sex matched controls were selected. Seed-based functional connectivity analyses were performed using seeds in the dorsolateral prefrontal cortex and the inferior parietal lobule, to test for differences in functional connectivity between groups, associations between physical activity and functional connectivity within TBI as well as differential associations between physical activity and functional connectivity between TBI and controls.
Seed-based connectivity analyses from the dorsolateral prefrontal cortex showed that those with a history of TBI had decreased positive connectivity between dorsolateral prefrontal cortex and intracalcarine cortex, lingual gyrus, and cerebellum, and increased positive connectivity between dorsolateral prefrontal cortex and cingulate gyrus and frontal pole in the TBI group. Results showed that higher physical activity was positively associated with increased connectivity between the dorsolateral prefrontal cortex and inferior temporal gyrus. Differential associations were observed between groups whereby the strength of the physical activity-functional connectivity association was different between the inferior parietal lobule and inferior temporal gyrus in TBI compared to controls.
Individuals with a history of TBI show functional connectivity alterations of the FPCN. Moreover, engagement in physical activity is associated with functional network connectivity of the FPCN in those with a TBI. These findings are consistent with the evidence that physical activity affects FPCN connectivity in non-injured adults; however, this effect presents differently in those with a history of TBI.
创伤性脑损伤（TBI）导致的功能网络连接的长期变化可能与 TBI 幸存者报告的长期认知主诉有关。尽管已经尝试了各种干预措施，但没有一种被证明对 TBI 后的长期认知主诉有效，而身体活动已被证明可以促进认知功能，并调节未受伤成年人的功能网络连接。因此，本研究的目的是测试身体活动参与是否与 TBI 病史成人的认知相关额顶控制网络（FPCN）的功能连接相关。
在病例对照研究设计中，对剑桥老龄化和神经科学中心（Cam-CAN）研究中一部分参与者（18-81 岁）的静息状态功能磁共振成像和身体活动数据进行了分析。57 名参与者报告有头部受伤史，伴有意识丧失，选择了 57 名年龄和性别匹配的对照者。使用背外侧前额叶皮层和下顶叶的种子进行基于种子的功能连接分析，以测试组间功能连接的差异、TBI 内身体活动与功能连接的相关性以及 TBI 与对照组之间身体活动与功能连接的差异相关性。
背外侧前额叶皮层的种子连接分析表明，TBI 组的背外侧前额叶皮层与内距状皮层、舌回和小脑之间的正连接减少，与扣带回和额极之间的正连接增加。结果表明，较高的身体活动与背外侧前额叶皮层和下颞叶之间的连接增加呈正相关。在组间观察到差异相关性，即与对照组相比，TBI 中下顶叶和下颞叶之间的身体活动-功能连接相关性的强度不同。
有 TBI 病史的个体表现出 FPCN 的功能连接改变。此外，身体活动参与与 TBI 个体的 FPCN 功能网络连接相关。这些发现与身体活动影响未受伤成年人 FPCN 连接的证据一致；然而，这种影响在有 TBI 病史的个体中表现不同。
