First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Department of Thyroid and Breast Surgery, The 960th Hospital of PLA Joint Logistics Support Force, Jinan, Shandong, China.
Brain Behav. 2024 Sep;14(9):e70046. doi: 10.1002/brb3.70046.
Some correlations between thyroid disorders and insomnia have been found in previous studies; however, the causal relationship between them is unclear. The aim of this study was to investigate the causal relationship between insomnia and five thyroid disorders (hyperthyroidism, hypothyroidism, thyroiditis, thyroid nodules, and thyroid cancer).
We assessed the causal relationship between insomnia and thyroid disorders using inverse variance weighted, weighted median, and Mendelian randomization (MR)-Egger analyses in MR analyses and then used inverse MR analyses to assess the causal relationship between thyroid disorders and insomnia.
MR analysis showed that insomnia did not increase the risk of hyperthyroidism, hypothyroidism, thyroiditis, thyroid nodules, and thyroid cancer. However, reverse MR analysis showed that thyroid cancer increased the risk of insomnia (OR = 1.01, 95%CI: 1.00-1.02, p = .01), and the other four thyroid disorders had no direct causal relationship with insomnia. Sensitivity analyses indicated that the results were robust and no pleiotropy or heterogeneity was detected.
This study did not find evidence of a bidirectional causal relationship between genetically predicted insomnia and hyperthyroidism, hypothyroidism, thyroiditis, and thyroid nodules. However, we found that although insomnia does not increase the risk of thyroid cancer, thyroid cancer does increase the risk of insomnia.
先前的研究发现甲状腺疾病与失眠之间存在一些相关性，但它们之间的因果关系尚不清楚。本研究旨在探讨失眠与五种甲状腺疾病（甲状腺功能亢进症、甲状腺功能减退症、甲状腺炎、甲状腺结节和甲状腺癌）之间的因果关系。
我们采用逆方差加权、加权中位数和 Mendelian 随机化（MR）- Egger 分析在 MR 分析中评估失眠与甲状腺疾病之间的因果关系，然后采用逆 MR 分析评估甲状腺疾病与失眠之间的因果关系。
MR 分析表明，失眠不会增加患甲状腺功能亢进症、甲状腺功能减退症、甲状腺炎、甲状腺结节和甲状腺癌的风险。然而，反向 MR 分析表明，甲状腺癌会增加失眠的风险（OR=1.01，95%CI：1.00-1.02，p=0.01），而其他四种甲状腺疾病与失眠之间没有直接的因果关系。敏感性分析表明结果稳健，未检测到混杂或异质性。
本研究未发现遗传预测的失眠与甲状腺功能亢进症、甲状腺功能减退症、甲状腺炎和甲状腺结节之间存在双向因果关系的证据。然而，我们发现尽管失眠不会增加甲状腺癌的风险，但甲状腺癌确实会增加失眠的风险。
